ADAM11#Further reading

{{Short description|Protein-coding gene in the species Homo sapiens}}

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.{{cite journal | vauthors = Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y | title = A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers | journal = Nat Genet | volume = 5 | issue = 2 | pages = 151–7 |date=Jan 1994| pmid = 8252040 | doi = 10.1038/ng1093-151 | s2cid = 11770397 }}{{cite web | title = Entrez Gene: ADAM11 ADAM metallopeptidase domain 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4185}}

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.

References

{{cite journal | vauthors=Wolfsberg TG, Primakoff P, Myles DG, White JM |title=ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell- matrix interactions |journal=J. Cell Biol. |volume=131 |issue= 2 |pages= 275–8 |year= 1995 |pmid= 7593158 |doi=10.1083/jcb.131.2.275 | pmc=2199973 }}
{{cite journal | vauthors=Katagiri T, Harada Y, Emi M, Nakamura Y |title=Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1–2 |pages= 39–44 |year= 1994 |pmid= 7956356 |doi=10.1159/000133884 }}
{{cite journal | vauthors=Sagane K, Ohya Y, Hasegawa Y, Tanaka I |title=Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain |journal=Biochem. J. |volume=334 ( Pt 1) |issue= Pt 1|pages= 93–8 |year= 1998 |pmid= 9693107 |doi= 10.1042/bj3340093| pmc=1219666 }}
{{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 |doi-access=free }}
{{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 |display-authors=etal}}
{{cite journal | vauthors=Fu GK, Wang JT, Yang J |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011 |display-authors=etal}}

External links

The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.976 M12.976]
{{UCSC gene info|ADAM11}}

Category:Proteases

Category:Human proteins

Category:EC 3.4.24