ADAM2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Use dmy dates|date=June 2016}}
{{Infobox_gene}}
Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin{{cite journal | vauthors = Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E | title = Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation | journal = Reproductive Biology and Endocrinology | volume = 9 | pages = 96 | date = June 2011 | pmid = 21718510 | doi = 10.1186/1477-7827-9-96 | pmc = 3141649 | doi-access = free }} is an enzyme that in humans is encoded by the ADAM2 gene.{{cite journal | vauthors = Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF | title = Molecular cloning of the human fertilin beta subunit | journal = Biochemical and Biophysical Research Communications | volume = 224 | issue = 2 | pages = 318–26 | date = July 1996 | pmid = 8702389 | doi = 10.1006/bbrc.1996.1027 }}{{cite journal | vauthors = Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA | title = Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB) | journal = Genomics | volume = 40 | issue = 1 | pages = 190–2 | date = February 1997 | pmid = 9070941 | doi = 10.1006/geno.1996.4531 }}{{cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515}}
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions. The other subunit is ADAM1 or alpha-fertilin.
References
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Further reading
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- {{cite journal | vauthors = Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y | title = Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions | journal = The Journal of Biological Chemistry | volume = 277 | issue = 20 | pages = 17804–10 | date = May 2002 | pmid = 11882657 | doi = 10.1074/jbc.M200086200 | doi-access = free }}
- {{cite journal | vauthors = Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M | title = Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility | journal = Developmental Biology | volume = 240 | issue = 1 | pages = 254–61 | date = December 2001 | pmid = 11784061 | doi = 10.1006/dbio.2001.0462 | doi-access = free }}
- {{cite journal | vauthors = Cho C, Ge H, Branciforte D, Primakoff P, Myles DG | title = Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion | journal = Developmental Biology | volume = 222 | issue = 2 | pages = 289–95 | date = June 2000 | pmid = 10837118 | doi = 10.1006/dbio.2000.9703 | doi-access = free }}
- {{cite journal | vauthors = Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM | title = Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 21 | pages = 11830–5 | date = October 1999 | pmid = 10518536 | pmc = 18372 | doi = 10.1073/pnas.96.21.11830 | bibcode = 1999PNAS...9611830C | doi-access = free }}
- {{cite journal | vauthors = Chen H, Sampson NS | title = Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta | journal = Chemistry & Biology | volume = 6 | issue = 1 | pages = 1–10 | date = January 1999 | pmid = 9889149 | doi = 10.1016/S1074-5521(99)80015-5 | doi-access = free }}
- {{cite journal | vauthors = Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Herr JC | title = Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member | journal = Molecular Reproduction and Development | volume = 46 | issue = 3 | pages = 363–9 | date = March 1997 | pmid = 9041139 | doi = 10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-# | s2cid = 196584546 }}
- {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = The Journal of Infection | volume = 24 | issue = 3 | pages = 317–20 | date = May 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
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External links
- The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.950 M12.950]
- {{UCSC gene info|ADAM2}}
{{Metalloendopeptidases}}
{{Enzymes}}
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{{DEFAULTSORT:Adam2}}
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