ADAM22

ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.

ADAM22 has been shown to interact with DLG4.{{cite journal | vauthors = Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M | title = Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission | journal = Science | volume = 313 | issue = 5794 | pages = 1792–5 | date = September 2006 | pmid = 16990550 | doi = 10.1126/science.1129947 | bibcode = 2006Sci...313.1792F | s2cid = 33024022 }}

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• {{cite journal | vauthors = Harada T, Nishie A, Torigoe K, Ikezaki K, Shono T, Maehara Y, Kuwano M, Wada M | title = The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 10 | pages = 1001–6 | date = October 2000 | pmid = 11050470 | doi = 10.1111/j.1349-7006.2000.tb00877.x | pmc = 5926265 }}
• {{cite journal | vauthors = ((Zhu Pc)), Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S | title = The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading | journal = Biochemical and Biophysical Research Communications | volume = 301 | issue = 4 | pages = 991–9 | date = February 2003 | pmid = 12589811 | doi = 10.1016/S0006-291X(03)00056-1 }}
• {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 | doi-access = free }}
• {{cite journal | vauthors = Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T | title = Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice | journal = BMC Neuroscience | volume = 6 | pages = 33 | year = 2006 | pmid = 15876356 | pmc = 1142324 | doi = 10.1186/1471-2202-6-33 | doi-access = free }}
• {{cite journal | vauthors = Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S | title = ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3 | journal = Biochemical and Biophysical Research Communications | volume = 331 | issue = 4 | pages = 938–46 | date = June 2005 | pmid = 15882968 | doi = 10.1016/j.bbrc.2005.03.229 }}
• {{cite journal | vauthors = D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U | title = ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain | journal = Neurosurgery | volume = 58 | issue = 1 | pages = 179–86; discussion 179–86 | date = January 2006 | pmid = 16385342 | doi = 10.1227/01.NEU.0000192363.84287.8B | s2cid = 24601244 }}
• {{cite journal | vauthors = Gödde NJ, D'Abaco GM, Paradiso L, Novak U | title = Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members | journal = Journal of Cell Science | volume = 119 | issue = Pt 16 | pages = 3296–305 | date = August 2006 | pmid = 16868027 | doi = 10.1242/jcs.03065 | doi-access = free }}
• {{cite journal | vauthors = Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M | title = Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission | journal = Science | volume = 313 | issue = 5794 | pages = 1792–5 | date = September 2006 | pmid = 16990550 | doi = 10.1126/science.1129947 | bibcode = 2006Sci...313.1792F | s2cid = 33024022 }}
• {{cite journal | vauthors = Chabrol E, Gourfinkel-An I, Scheffer IE, Picard F, Couarch P, Berkovic SF, McMahon JM, Bajaj N, Mota-Vieira L, Mota R, Trouillard O, Depienne C, Baulac M, LeGuern E, Baulac S | title = Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy | journal = Epilepsy Research | volume = 76 | issue = 1 | pages = 41–8 | date = August 2007 | pmid = 17681454 | doi = 10.1016/j.eplepsyres.2007.06.014 | s2cid = 28172409 | url = http://www.hal.inserm.fr/inserm-00306474/file/Chabrol_et_al_Epi_Research-2007.pdf }}
• {{cite journal | vauthors = Gödde NJ, D'Abaco GM, Paradiso L, Novak U | title = Differential coding potential of ADAM22 mRNAs | journal = Gene | volume = 403 | issue = 1–2 | pages = 80–8 | date = November 2007 | pmid = 17884303 | doi = 10.1016/j.gene.2007.07.033 }}

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• The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.978 M12.978]
• {{UCSC gene info|ADAM22}}

{{Metalloendopeptidases}}

{{Enzymes}}

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Category:Proteases

Category:Human proteins

Category:EC 3.4.24

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