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ADAMTS8

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.{{cite journal | vauthors = Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML | title = METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity | journal = J Biol Chem | volume = 274 | issue = 33 | pages = 23349–57 |date=Sep 1999| pmid = 10438512 | doi =10.1074/jbc.274.33.23349 | doi-access = free }}{{cite web | title = Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11095}}

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.

Clinical significance

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

References

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Further reading

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  • {{cite journal | vauthors=Wågsäter D, Björk H, Zhu C |title=ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. |journal=Atherosclerosis |volume=196 |issue= 2 |pages= 514–22 |year= 2008 |pmid= 17606262 |doi= 10.1016/j.atherosclerosis.2007.05.018 |display-authors=etal}}
  • {{cite journal | vauthors=Dunn JR, Reed JE, du Plessis DG |title=Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. |journal=Br. J. Cancer |volume=94 |issue= 8 |pages= 1186–93 |year= 2006 |pmid= 16570050 |doi= 10.1038/sj.bjc.6603006 | pmc=2361255 |display-authors=etal}}
  • {{cite journal | vauthors=Porter S, Span PN, Sweep FC |title=ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1241–7 |year= 2006 |pmid= 16152618 |doi= 10.1002/ijc.21476 |s2cid=20711295 |display-authors=etal}}
  • {{cite journal | vauthors=Dunn JR, Panutsopulos D, Shaw MW |title=METH-2 silencing and promoter hypermethylation in NSCLC. |journal=Br. J. Cancer |volume=91 |issue= 6 |pages= 1149–54 |year= 2004 |pmid= 15328519 |doi= 10.1038/sj.bjc.6602107 | pmc=2747718 |display-authors=etal}}
  • {{cite journal | vauthors=Collins-Racie LA, Flannery CR, Zeng W |title=ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. |journal=Matrix Biol. |volume=23 |issue= 4 |pages= 219–30 |year= 2005 |pmid= 15296936 |doi= 10.1016/j.matbio.2004.05.004 |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Georgiadis KE, Hirohata S, Seldin MF, Apte SS |title=ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. |journal=Genomics |volume=62 |issue= 2 |pages= 312–5 |year= 2000 |pmid= 10610729 |doi= 10.1006/geno.1999.6014 }}

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External links

  • The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.226 M12.226]
  • {{UCSC gene info|ADAMTS8}}

{{NLM content}}

{{Metalloproteinases}}

Category:ADAMTS

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