ADCK5

ADCK5 (aarF domain containing kinase 5) is an enzyme that in humans is encoded by the ADCK5 gene. It is situated on chromosome 8 at the q24.3 location.

Function

ADCK5 is predicted to possess protein serine/threonine kinase activity and to be an integral component of the membrane.{{cite web | url=https://www.ncbi.nlm.nih.gov/gene/203054 | title=ADCK5 aarF domain containing kinase 5 [Homo sapiens (Human)] - Gene - NCBI }}

Genomic context

The ADCK5 gene is located on chromosome 8q24.3. The genomic sequence spans 20,154 base pairs from 144,373,088 to 144,393,242 on the GRCh38.p14 primary assembly. It consists of 19 exons.

Expression

ADCK5 is ubiquitously expressed across various human tissues, with notable expression in the duodenum and small intestine, among others.

Clinical significance

Research indicates that ADCK5 may have therapeutic implications in lung cancer.{{cite journal |last1=Qiu |first1=M |last2=Li |first2=G |last3=Wang |first3=P |last4=Li |first4=X |last5=Lai |first5=F |last6=Luo |first6=R |last7=Liu |first7=B |last8=Lin |first8=J |title=aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway. |journal=Experimental Cell Research |date=1 July 2020 |volume=392 |issue=1 |pages=112002 |doi=10.1016/j.yexcr.2020.112002 |pmid=32277958}}

References

Category:EC 2.7.11

Category:Genes on human chromosome 14