ADCY1

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central

nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.{{cite web | title = Gene Cards: ADCY1 Gene| url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADCY1| access-date = 2012-12-30}}

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• {{UCSC gene info|ADCY1}}

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• {{cite journal | vauthors = Osawa S, Dhanasekaran N, Woon CW, Johnson GL | title = G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions | journal = Cell | volume = 63 | issue = 4 | pages = 697–706 | date = Nov 1990 | pmid = 2121366 | doi = 10.1016/0092-8674(90)90136-3 | s2cid = 53254447 }}
• {{cite journal | vauthors = Gaudin C, Homcy CJ, Ishikawa Y | title = Mammalian adenylyl cyclase family members are randomly located on different chromosomes | journal = Human Genetics | volume = 94 | issue = 5 | pages = 527–9 | date = Nov 1994 | pmid = 7959689 | doi = 10.1007/BF00211020 | s2cid = 40521157 }}
• {{cite journal | vauthors = Whisnant RE, Gilman AG, Dessauer CW | title = Interaction of the two cytosolic domains of mammalian adenylyl cyclase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6621–5 | date = Jun 1996 | pmid = 8692867 | pmc = 39075 | doi = 10.1073/pnas.93.13.6621 | bibcode = 1996PNAS...93.6621W | doi-access = free }}
• {{cite journal | vauthors = Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP | title = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 | journal = Pflügers Archiv | volume = 437 | issue = 4 | pages = 538–46 | date = Mar 1999 | pmid = 10089566 | doi = 10.1007/s004240050815 | s2cid = 7620262 }}
• {{cite journal | vauthors = Speth C, Joebstl B, Barcova M, Dierich MP | title = HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones | journal = AIDS | volume = 14 | issue = 6 | pages = 629–36 | date = Apr 2000 | pmid = 10807185 | doi = 10.1097/00002030-200004140-00001 | s2cid = 22105709 | doi-access = free }}
• {{cite journal | vauthors = Patke CL, Shearer WT | title = gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression | journal = The Journal of Allergy and Clinical Immunology | volume = 105 | issue = 5 | pages = 975–82 | date = May 2000 | pmid = 10808179 | doi = 10.1067/mai.2000.105315 | doi-access = free }}
• {{cite journal | vauthors = Patrizio M, Colucci M, Levi G | title = Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures | journal = Journal of Neurochemistry | volume = 77 | issue = 2 | pages = 399–407 | date = Apr 2001 | pmid = 11299302 | doi = 10.1046/j.1471-4159.2001.00249.x | s2cid = 24053412 | doi-access = free }}
• {{cite journal | vauthors = Côté M, Guillon G, Payet MD, Gallo-Payet N | title = Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 9 | pages = 4495–503 | date = Sep 2001 | doi = 10.1210/jcem.86.9.7837 | pmid = 11549699 | doi-access = free }}
• {{cite journal | vauthors = Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP | title = Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons | journal = Journal of Virology | volume = 76 | issue = 7 | pages = 3179–88 | date = Apr 2002 | pmid = 11884542 | pmc = 136041 | doi = 10.1128/JVI.76.7.3179-3188.2002 }}
• {{cite journal | vauthors = Ludwig MG, Seuwen K | title = Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms | journal = Journal of Receptor and Signal Transduction Research | volume = 22 | issue = 1–4 | pages = 79–110 | year = 2003 | pmid = 12503609 | doi = 10.1081/RRS-120014589 | s2cid = 36697419 }}
• {{cite journal | vauthors = Tucholski J, Johnson GV | title = Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26838–43 | date = Jul 2003 | pmid = 12743114 | doi = 10.1074/jbc.M303683200 | doi-access = free }}
• {{cite journal | vauthors = Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR | title = Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP | journal = Nature Neuroscience | volume = 7 | issue = 6 | pages = 635–42 | date = Jun 2004 | pmid = 15133516 | doi = 10.1038/nn1248 | s2cid = 17443260 }}
• {{cite journal | vauthors = Vortherms TA, Nguyen CH, Berlot CH, Watts VJ | title = Using molecular tools to dissect the role of Galphas in sensitization of AC1 | journal = Molecular Pharmacology | volume = 66 | issue = 6 | pages = 1617–24 | date = Dec 2004 | pmid = 15361543 | doi = 10.1124/mol.104.000166 | s2cid = 35188792 }}
• {{cite journal | vauthors = Weber B, Schaper C, Scholz J, Bein B, Rodde C, H Tonner P | title = Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase | journal = Cellular Signalling | volume = 18 | issue = 10 | pages = 1748–57 | date = Oct 2006 | pmid = 16531006 | doi = 10.1016/j.cellsig.2006.01.017 }}
• {{cite journal | vauthors = Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M | title = Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia | journal = FEBS Letters | volume = 581 | issue = 17 | pages = 3241–6 | date = Jul 2007 | pmid = 17586501 | pmc = 1986749 | doi = 10.1016/j.febslet.2007.06.015 }}

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Category:EC 4.6.1

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