ADCY4

This gene encodes a member of the family of adenylyl cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylyl cyclase 4, along with adenylyl cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylyl cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.

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• {{UCSC gene info|ADCY4}}

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• {{cite journal | vauthors=Gaudin C, Homcy CJ, Ishikawa Y |title=Mammalian adenylyl cyclase family members are randomly located on different chromosomes |journal=Hum. Genet. |volume=94 |issue= 5 |pages= 527–9 |year= 1994 |pmid= 7959689 |doi=10.1007/BF00211020 |s2cid=40521157 }}
• {{cite journal | vauthors=Barcova M, Speth C, Kacani L |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 |journal=Pflügers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=10.1007/s004240050815 |s2cid=7620262 |display-authors=etal}}
• {{cite journal | vauthors=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=10.1097/00002030-200004140-00001 |s2cid=22105709 |doi-access=free }}
• {{cite journal | vauthors=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 |doi-access= free }}
• {{cite journal | vauthors=Wong ST, Trinh K, Hacker B |title=Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice |journal=Neuron |volume=27 |issue= 3 |pages= 487–97 |year= 2000 |pmid= 11055432 |doi=10.1016/S0896-6273(00)00060-X |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=10.1046/j.1471-4159.2001.00249.x |doi-access=free }}
• {{cite journal | vauthors=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495–503 |year= 2001 |doi=10.1210/jcem.86.9.7837 |pmid= 11549699 |doi-access=free }}
• {{cite journal | vauthors=Speth C, Schabetsberger T, Mohsenipour I |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=10.1128/JVI.76.7.3179-3188.2002 | pmc=136041 |display-authors=etal}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1–4 |pages= 79–110 |year= 2003 |pmid= 12503609 |doi=10.1081/RRS-120014589 |s2cid=36697419 }}
• {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

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Category:EC 4.6.1

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