ADH1A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.{{cite book | author = Smith M | title = Advances in Human Genetics vol. 15 | chapter = Genetics of Human Alcohol and Aldehyde Dehydrogenases | pages = 249–90 |date=Mar 1986| volume = 15 | pmid = 3006456 | doi =10.1007/978-1-4615-8356-1_5 | isbn = 978-1-4615-8358-5 }}
This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.{{cite web | title = Entrez Gene: ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Lange LG, Sytkowski AJ, Vallee BL |title=Human liver alcohol dehydrogenase: purification, composition, and catalytic features |journal=Biochemistry |volume=15 |issue= 21 |pages= 4687–93 |year= 1976 |pmid= 9982 |doi=10.1021/bi00666a023 }}
- {{cite journal | vauthors=van Ooij C, Snyder RC, Paeper BW, Duester G |title=Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein |journal=Mol. Cell. Biol. |volume=12 |issue= 7 |pages= 3023–31 |year= 1992 |pmid= 1620113 |doi= 10.1128/mcb.12.7.3023| pmc=364516 }}
- {{cite journal | vauthors=Stewart MJ, McBride MS, Winter LA, Duester G |title=Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box |journal=Gene |volume=90 |issue= 2 |pages= 271–9 |year= 1990 |pmid= 2169444 |doi=10.1016/0378-1119(90)90190-3 }}
- {{cite journal | vauthors=Yasunami M, Kikuchi I, Sarapata D, Yoshida A |title=The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome |journal=Genomics |volume=7 |issue= 2 |pages= 152–8 |year= 1990 |pmid= 2347582 |doi=10.1016/0888-7543(90)90535-3 }}
- {{cite journal | vauthors=Tsukahara M, Yoshida A |title=Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization |journal=Genomics |volume=4 |issue= 2 |pages= 218–20 |year= 1989 |pmid= 2737681 |doi=10.1016/0888-7543(89)90304-2 }}
- {{cite journal | vauthors=Matsuo Y, Yokoyama S |title=Molecular structure of the human alcohol dehydrogenase 1 gene |journal=FEBS Lett. |volume=243 |issue= 1 |pages= 57–60 |year= 1989 |pmid= 2920825 |doi=10.1016/0014-5793(89)81217-7 |s2cid=46240593 |doi-access=free }}
- {{cite journal | vauthors=Ikuta T, Szeto S, Yoshida A |title=Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 3 |pages= 634–8 |year= 1986 |pmid= 2935875 |doi=10.1073/pnas.83.3.634 | pmc=322918 |bibcode=1986PNAS...83..634I |doi-access=free }}
- {{cite journal | vauthors=von Bahr-Lindström H, Höög JO, Hedén LO |title=cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase |journal=Biochemistry |volume=25 |issue= 9 |pages= 2465–70 |year= 1986 |pmid= 3013304 |doi=10.1021/bi00357a026 |display-authors=etal}}
- {{cite journal | vauthors=Duester G, Farrés J, Felder MR |title=Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family |journal=Biochem. Pharmacol. |volume=58 |issue= 3 |pages= 389–95 |year= 1999 |pmid= 10424757 |doi=10.1016/S0006-2952(99)00065-9 |display-authors=etal}}
- {{cite journal | vauthors=Rodriguez-Zavala JS, Weiner H |title=Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation |journal=Biochemistry |volume=41 |issue= 26 |pages= 8229–37 |year= 2002 |pmid= 12081471 |doi=10.1021/bi012081x }}
- {{cite journal | vauthors=Sandberg M, Yasar U, Strömberg P |title=Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase |journal=British Journal of Clinical Pharmacology |volume=54 |issue= 4 |pages= 423–9 |year= 2003 |pmid= 12392591 |doi=10.1046/j.1365-2125.2002.01660.x | pmc=1874434 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Dannenberg LO, Chen HJ, Edenberg HJ |title=GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene |journal=DNA Cell Biol. |volume=24 |issue= 9 |pages= 543–52 |year= 2006 |pmid= 16153155 |doi= 10.1089/dna.2005.24.543 }}
- {{cite journal | vauthors=Jelski W, Chrostek L, Szmitkowski M |title=The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer |journal=Pancreas |volume=35 |issue= 2 |pages= 142–6 |year= 2007 |pmid= 17632320 |doi= 10.1097/MPA.0b013e318053eae2 |s2cid=519403 }}
{{refend}}
External links
- {{UCSC gene info|ADH1A}}
{{PDB Gallery|geneid=124}}
{{gene-4-stub}}