ADH1C

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.{{cite web | title = Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126}}

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• {{cite journal | vauthors = Seitz HK, Meier P | title = The role of acetaldehyde in upper digestive tract cancer in alcoholics | journal = Translational Research | volume = 149 | issue = 6 | pages = 293–7 | date = Jun 2007 | pmid = 17543846 | doi = 10.1016/j.trsl.2006.12.002 }}
• {{cite journal | vauthors = Lange LG, Sytkowski AJ, Vallee BL | title = Human liver alcohol dehydrogenase: purification, composition, and catalytic features | journal = Biochemistry | volume = 15 | issue = 21 | pages = 4687–93 | date = Oct 1976 | pmid = 9982 | doi = 10.1021/bi00666a023 }}
• {{cite journal | vauthors = Yokoyama S, Matsuo Y, Rajasekharan S, Yokoyama R | title = Molecular structure of the human alcohol dehydrogenase 3 gene | journal = Idengaku Zasshi | volume = 67 | issue = 2 | pages = 167–71 | date = Apr 1992 | pmid = 1524834 | doi = 10.1266/jjg.67.167 | doi-access = free }}
• {{cite journal | vauthors = Hurley TD, Bosron WF, Hamilton JA, Amzel LM | title = Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 18 | pages = 8149–53 | date = Sep 1991 | pmid = 1896463 | pmc = 52464 | doi = 10.1073/pnas.88.18.8149 | bibcode = 1991PNAS...88.8149H | doi-access = free }}
• {{cite journal | vauthors = Stewart MJ, McBride MS, Winter LA, Duester G | title = Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box | journal = Gene | volume = 90 | issue = 2 | pages = 271–9 | date = Jun 1990 | pmid = 2169444 | doi = 10.1016/0378-1119(90)90190-3 }}
• {{cite journal | vauthors = Yasunami M, Kikuchi I, Sarapata D, Yoshida A | title = The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome | journal = Genomics | volume = 7 | issue = 2 | pages = 152–8 | date = Jun 1990 | pmid = 2347582 | doi = 10.1016/0888-7543(90)90535-3 }}
• {{cite journal | vauthors = Tsukahara M, Yoshida A | title = Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization | journal = Genomics | volume = 4 | issue = 2 | pages = 218–20 | date = Feb 1989 | pmid = 2737681 | doi = 10.1016/0888-7543(89)90304-2 }}
• {{cite journal | vauthors = Ikuta T, Szeto S, Yoshida A | title = Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 3 | pages = 634–8 | date = Feb 1986 | pmid = 2935875 | pmc = 322918 | doi = 10.1073/pnas.83.3.634 | bibcode = 1986PNAS...83..634I | doi-access = free }}
• {{cite journal | vauthors = Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ | title = Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification | journal = Genomics | volume = 2 | issue = 3 | pages = 209–14 | date = Apr 1988 | pmid = 3397059 | doi = 10.1016/0888-7543(88)90004-3 }}
• {{cite journal | vauthors = Höög JO, Hedén LO, Larsson K, Jörnvall H, von Bahr-Lindström H | title = The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties | journal = European Journal of Biochemistry | volume = 159 | issue = 2 | pages = 215–8 | date = Sep 1986 | pmid = 3758060 | doi = 10.1111/j.1432-1033.1986.tb09855.x | doi-access = free }}
• {{cite journal | vauthors = Bühler R, Hempel J, Kaiser R, de Zalenski C, von Wartburg JP, Jörnvall H | title = Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain | journal = European Journal of Biochemistry | volume = 145 | issue = 3 | pages = 447–53 | date = Dec 1984 | pmid = 6391921 | doi = 10.1111/j.1432-1033.1984.tb08575.x | doi-access = free }}
• {{cite journal | vauthors = Cheung B, Anderson JK, Holmes RS, Beacham IR | title = Human stomach class IV alcohol dehydrogenase: molecular genetic analysis | journal = Alcoholism: Clinical and Experimental Research | volume = 19 | issue = 1 | pages = 185–6 | date = Feb 1995 | pmid = 7771649 | doi = 10.1111/j.1530-0277.1995.tb01490.x }}
• {{cite journal | vauthors = Hurley TD, Bosron WF, Stone CL, Amzel LM | title = Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences | journal = Journal of Molecular Biology | volume = 239 | issue = 3 | pages = 415–29 | date = Jun 1994 | pmid = 8201622 | doi = 10.1006/jmbi.1994.1382 | doi-access = free }}
• {{cite journal | vauthors = Cheung C, Smith CK, Hoog JO, Hotchkiss SA | title = Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin | journal = Biochemical and Biophysical Research Communications | volume = 261 | issue = 1 | pages = 100–7 | date = Jul 1999 | pmid = 10405330 | doi = 10.1006/bbrc.1999.0943 }}
• {{cite journal | vauthors = Duester G, Farrés J, Felder MR, Holmes RS, Höög JO, Parés X, Plapp BV, Yin SJ, Jörnvall H | title = Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family | journal = Biochemical Pharmacology | volume = 58 | issue = 3 | pages = 389–95 | date = Aug 1999 | pmid = 10424757 | doi = 10.1016/S0006-2952(99)00065-9 }}
• {{cite journal | vauthors = Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD | title = Three-dimensional structures of the three human class I alcohol dehydrogenases | journal = Protein Science | volume = 10 | issue = 4 | pages = 697–706 | date = Apr 2001 | pmid = 11274460 | pmc = 2373965 | doi = 10.1110/ps.45001 }}
• {{cite journal | vauthors = Osier MV, Pakstis AJ, Goldman D, Edenberg HJ, Kidd JR, Kidd KK | title = A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans | journal = Alcoholism: Clinical and Experimental Research | volume = 26 | issue = 12 | pages = 1759–63 | date = Dec 2002 | pmid = 12500098 | doi = 10.1111/j.1530-0277.2002.tb02481.x}}

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• {{UCSC gene info|ADH1C}}

{{PDB Gallery|geneid=126}}

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