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AFAP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.{{cite journal | vauthors = Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC | title = Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity | journal = J Cell Biochem | volume = 91 | issue = 3 | pages = 602–20 |date=Feb 2004 | pmid = 14755689 | doi = 10.1002/jcb.10725 | s2cid = 38130241 }}{{cite journal | vauthors = Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC | title = The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases | journal = Oncogene | volume = 20 | issue = 45 | pages = 6607–16 |date=Oct 2001 | pmid = 11641786 | doi = 10.1038/sj.onc.1204802 | doi-access = | s2cid = 21926408 }}{{cite journal | vauthors = Baisden JM, Qian Y, Zot HM, Flynn DC | title = The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity | journal = Oncogene | volume = 20 | issue = 44 | pages = 6435–47 |date=Oct 2001 | pmid = 11607843 | doi = 10.1038/sj.onc.1204784 | doi-access = free }}{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312}}

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.

References

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External links

  • {{UCSC gene info|AFAP1}}

Further reading

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  • {{cite journal | vauthors=Ishida Y, Hadano S, Nagayama T |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302–12 |year= 1995 |pmid= 7545969 |doi=10.1006/geno.1994.1388 |display-authors=etal}}
  • {{cite journal | vauthors=Qian Y, Baisden JM, Westin EH |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185–95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753 |display-authors=etal|doi-access= |s2cid=28373925 }}
  • {{cite journal | vauthors=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110–9 |year= 1998 |pmid= 9655255 |doi=10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q |s2cid=10461528 }}
  • {{cite journal | vauthors=Qian Y, Baisden JM, Zot HG |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102–13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795 |display-authors=etal}}
  • {{cite journal | vauthors=Qian Y, Baisden JM, Cherezova L |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311–22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148 | pmc=117315 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 |display-authors=etal}}
  • {{cite journal | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Dorfleutner A, Stehlik C, Zhang J |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740–9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143 |display-authors=etal|citeseerx=10.1.1.636.3591 |s2cid=15344259 }}

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