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AGTRAP

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.{{cite journal | vauthors = Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y | title = Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap) | journal = Int J Biochem Cell Biol | volume = 34 | issue = 1 | pages = 93–102 |date=Dec 2001 | pmid = 11733189 | doi =10.1016/S1357-2725(01)00094-2 }}{{cite web | title = Entrez Gene: AGTRAP angiotensin II receptor-associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57085}}

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Interactions

AGTRAP has been shown to interact with GNB2L1.

References

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External links

  • {{UCSC gene info|AGTRAP}}

Further reading

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  • {{cite journal | vauthors=Daviet L, Lehtonen JY, Tamura K |title=Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17058–62 |year= 1999 |pmid= 10358057 |doi=10.1074/jbc.274.24.17058 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Cui T, Nakagami H, Iwai M |title=ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 938–41 |year= 2001 |pmid= 11162453 |doi= 10.1006/bbrc.2000.4055 |display-authors=etal}}
  • {{cite journal | vauthors=Wistow G, Bernstein SL, Wyatt MK |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants |journal=Mol. Vis. |volume=8 |pages= 171–84 |year= 2002 |pmid= 12107413 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ |title=The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 5038–50 |year= 2004 |pmid= 12960423 |doi= 10.1091/mbc.E03-06-0383 | pmc=284805 }}
  • {{cite journal | vauthors=Guo DF, Chenier I, Tardif V |title=Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1254–65 |year= 2003 |pmid= 14559250 |doi=10.1016/j.bbrc.2003.09.154 |display-authors=etal}}
  • {{cite journal | vauthors=Guo DF, Tardif V, Ghelima K |title=A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21109–20 |year= 2004 |pmid= 14985364 |doi= 10.1074/jbc.M401544200 |display-authors=etal|doi-access= free}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Guo S, Lopez-Ilasaca M, Dzau VJ |title=Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12536–41 |year= 2005 |pmid= 15668245 |doi= 10.1074/jbc.M500296200 |doi-access= free }}
  • {{cite journal | vauthors=Tanaka Y, Tamura K, Koide Y |title=The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1579–86 |year= 2005 |pmid= 15757644 |doi= 10.1016/j.febslet.2005.01.068 |display-authors=etal|doi-access= |s2cid=36456303 }}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}

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