AKAP7
{{Short description|Protein-coding gene in the species Homo sapiens}}
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A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.{{cite journal | vauthors = Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD | title = A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events | journal = The EMBO Journal | volume = 17 | issue = 8 | pages = 2261–2272 | date = Apr 1998 | pmid = 9545239 | pmc = 1170570 | doi = 10.1093/emboj/17.8.2261 }}{{cite web | title = Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9465| accessdate = }}
Function
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.
References
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External links
- {{UCSC gene info|AKAP7}}
Further reading
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- {{cite journal | vauthors = Gold MG, Smith FD, Scott JD, Barford D | title = AKAP18 contains a phosphoesterase domain that binds AMP | journal = Journal of Molecular Biology | volume = 375 | issue = 5 | pages = 1329–1343 | date = Feb 2008 | pmid = 18082768 | pmc = 3188456 | doi = 10.1016/j.jmb.2007.11.037 }}
- {{cite journal | vauthors = Bengrine A, Li J, Awayda MS | title = The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel | journal = FASEB Journal | volume = 21 | issue = 4 | pages = 1189–1201 | date = Apr 2007 | pmid = 17244820 | doi = 10.1096/fj.06-6046com | doi-access = free | s2cid = 34457423 }}
- {{cite journal | vauthors = Brown RL, August SL, Williams CJ, Moss SB | title = AKAP7gamma is a nuclear RI-binding AKAP | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 2 | pages = 394–401 | date = Jun 2003 | pmid = 12804576 | doi = 10.1016/S0006-291X(03)00982-3 }}
- {{cite journal | vauthors = Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD | title = Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 8 | pages = 4445–4450 | date = Apr 2003 | pmid = 12672969 | pmc = 153575 | doi = 10.1073/pnas.0330734100 | bibcode = 2003PNAS..100.4445A | doi-access = free }}
- {{cite journal | vauthors = Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL | title = Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms | journal = The Journal of Cell Biology | volume = 147 | issue = 7 | pages = 1481–1492 | date = Dec 1999 | pmid = 10613906 | pmc = 2174236 | doi = 10.1083/jcb.147.7.1481 }}
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