AKAP8

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.

AKAP8 has been demonstrated to interact with:

• Cyclin D3{{cite journal | date = Mar 2004 | vauthors = Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I | title = A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95 | journal = Biochem. J. | volume = 378 | issue = Pt 2 | pages = 673–9 | pmid = 14641107 | pmc = 1223988 | doi = 10.1042/BJ20031765}}
• DDX5,{{cite journal | date = May 2001 | vauthors = Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM | title = A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17448–54 | pmid = 11279182 | doi = 10.1074/jbc.M101171200| doi-access = free }}
• MCM2,{{cite journal | date = Jul 2003 | vauthors = Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P | title = Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 26750–6 | pmid = 12740381 | doi = 10.1074/jbc.M300765200| doi-access = free }}
• MYCBP,{{cite journal | date = Dec 2002 | vauthors = Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H | title = AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50885–92 | pmid = 12414807 | doi = 10.1074/jbc.M206387200| doi-access = free }} and
• PRKAR2A.{{cite journal | date = Dec 1999 | vauthors = Collas P, Le Guellec K, Taskén K | title = The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1167–80 | pmid = 10601332 | pmc = 2168084 | doi = 10.1083/jcb.147.6.1167}}

{{Reflist}}

{{Refbegin | 2}}

• {{cite journal | vauthors=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 }}
• {{cite journal | vauthors=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }}
• {{cite journal | vauthors=Collas P, Le Guellec K, Taskén K |title=The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1167–80 |year= 2000 |pmid= 10601332 |doi=10.1083/jcb.147.6.1167 | pmc=2168084 }}
• {{cite journal | vauthors=Steen RL, Cubizolles F, Le Guellec K, Collas P |title=A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 531–6 |year= 2000 |pmid= 10791967 |doi=10.1083/jcb.149.3.531 | pmc=2174845 }}
• {{cite journal | vauthors=Akileswaran L, Taraska JW, Sayer JA |title=A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17448–54 |year= 2001 |pmid= 11279182 |doi= 10.1074/jbc.M101171200 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Eide T, Carlson C, Taskén KA |title=Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. |journal=EMBO Rep. |volume=3 |issue= 5 |pages= 426–32 |year= 2002 |pmid= 11964380 |doi= 10.1093/embo-reports/kvf089 | pmc=1084102 |display-authors=etal}}
• {{cite journal | vauthors=Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H |title=AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50885–92 |year= 2003 |pmid= 12414807 |doi= 10.1074/jbc.M206387200 |doi-access= free }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Eide T, Taskén KA, Carlson C |title=Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26750–6 |year= 2003 |pmid= 12740381 |doi= 10.1074/jbc.M300765200 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Arsenijevic T, Degraef C, Dumont JE |title=A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 673–9 |year= 2004 |pmid= 14641107 |doi= 10.1042/BJ20031765 | pmc=1223988 |display-authors=etal}}
• {{cite journal | vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 |display-authors=etal}}
• {{cite journal | vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Kamada S, Kikkawa U, Tsujimoto Y, Hunter T |title=A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. |journal=Mol. Cell. Biol. |volume=25 |issue= 21 |pages= 9469–77 |year= 2005 |pmid= 16227597 |doi= 10.1128/MCB.25.21.9469-9477.2005 | pmc=1265837 }}
• {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
• {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

{{Refend}}

• {{UCSC genome browser|AKAP8}}
• {{UCSC gene details|AKAP8}}

{{Gene-19-stub}}

Category:A-kinase-anchoring proteins