ALCAM

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.{{cite journal | vauthors = Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U | title = Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand | journal = J Exp Med | volume = 181 | issue = 6 | pages = 2213–20 |date=Jun 1995 | pmid = 7760007 | pmc = 2192054 | doi =10.1084/jem.181.6.2213 |display-authors=etal}}{{cite web | title = Entrez Gene: ALCAM activated leukocyte cell adhesion molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=214}} It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.{{citation needed|date=July 2017}} CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanom--a.{{cite journal | vauthors=Degen WG, van Kempen LC, Gijzen EG |title=MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). |journal=Am. J. Pathol. |volume=152 |issue= 3 |pages= 805–13 |year= 1998 |pmid= 9502422 | pmc=1858405 |display-authors=etal }} CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.{{citation needed|date=July 2017}}

Recently, CD166 has also been used as a potential cancer stem cell marker.{{citation needed|date=July 2017}}

See also

References

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Further reading

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  • {{cite journal | vauthors=Whitney GS, Starling GC, Bowen MA |title=The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18187–90 |year= 1995 |pmid= 7543097 |doi=10.1074/jbc.270.31.18187 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bajorath J, Bowen MA, Aruffo A |title=Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. |journal=Protein Sci. |volume=4 |issue= 8 |pages= 1644–7 |year= 1996 |pmid= 8520490 |doi=10.1002/pro.5560040822 | pmc=2143187 }}
  • {{cite journal | vauthors=Skonier JE, Bowen MA, Emswiler J |title=Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. |journal=Biochemistry |volume=35 |issue= 38 |pages= 12287–91 |year= 1996 |pmid= 8823162 |doi= 10.1021/bi961038k |display-authors=etal}}
  • {{cite journal | vauthors=Singer NG, Mitra R, Lialios F |title=CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes. |journal=Immunol. Lett. |volume=58 |issue= 1 |pages= 9–14 |year= 1998 |pmid= 9436462 |doi=10.1016/S0165-2478(97)02707-7 |display-authors=etal}}
  • {{cite journal | vauthors=Degen WG, van Kempen LC, Gijzen EG |title=MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). |journal=Am. J. Pathol. |volume=152 |issue= 3 |pages= 805–13 |year= 1998 |pmid= 9502422 | pmc=1858405 |display-authors=etal}}
  • {{cite journal | vauthors=Cortés F, Deschaseaux F, Uchida N |title=HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues. |journal=Blood |volume=93 |issue= 3 |pages= 826–37 |year= 1999 |pmid= 9920831 |doi= 10.1182/blood.V93.3.826|display-authors=etal}}
  • {{cite journal | vauthors=Tomita K, van Bokhoven A, Jansen CF |title=Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 3 |pages= 870–4 |year= 2000 |pmid= 10673383 |doi= 10.1006/bbrc.1999.2040 |display-authors=etal}}
  • {{cite journal | vauthors=van Kempen LC, Nelissen JM, Degen WG |title=Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25783–90 |year= 2001 |pmid= 11306570 |doi= 10.1074/jbc.M011272200 |display-authors=etal|doi-access=free |hdl=2066/143807 |hdl-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Kristiansen G, Pilarsky C, Wissmann C |title=ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions. |journal=Prostate |volume=54 |issue= 1 |pages= 34–43 |year= 2003 |pmid= 12481253 |doi= 10.1002/pros.10161 |s2cid=22749852 |display-authors=etal}}
  • {{cite journal | vauthors=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 |s2cid=581283 }}
  • {{cite journal | vauthors=Fujiwara H, Tatsumi K, Kosaka K |title=Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 7 |pages= 3437–43 |year= 2003 |pmid= 12843199 |doi=10.1210/jc.2002-021888 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=van Kempen LC, Meier F, Egeblad M |title=Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1293–301 |year= 2004 |pmid= 15140234 |doi= 10.1111/j.0022-202X.2004.22531.x |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Zimmerman AW, Nelissen JM, van Emst-de Vries SE |title=Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases. |journal=J. Cell Sci. |volume=117 |issue= Pt 13 |pages= 2841–52 |year= 2005 |pmid= 15169840 |doi= 10.1242/jcs.01139 |display-authors=etal|doi-access=free |hdl=2066/57147 |hdl-access=free }}
  • {{cite journal | vauthors=Ikeda K, Quertermous T |title=Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55315–23 |year= 2005 |pmid= 15496415 |doi= 10.1074/jbc.M407776200 |doi-access= free }}
  • {{cite journal | vauthors=Verma A, Shukla NK, Deo SV |title=MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma. |journal=Oncology |volume=68 |issue= 4–6 |pages= 462–70 |year= 2005 |pmid= 16024937 |doi= 10.1159/000086989 |s2cid=25355369 |display-authors=etal}}
  • {{cite journal | vauthors=Lunter PC, van Kilsdonk JW, van Beek H |title=Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity |journal=Cancer Res. |volume=65 |issue= 19 |pages= 8801–8 |year= 2005 |pmid= 16204050 |doi= 10.1158/0008-5472.CAN-05-0378 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}

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