ALG1

The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. The Alg1 mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.{{cite web | title = Entrez Gene: ALG1 asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56052}} Clinically, the deficiency of ALG1 in humans results in ALG1-CDG, a congenital disorder of glycosylation.{{cite web|url=https://www.omim.org/entry/608540|title=# 608540 CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ik; CDG1K | publisher=Johns Hopkins University | access-date = 2019-05-01}}

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• {{cite journal | vauthors = Couto JR, Huffaker TC, Robbins PW | title = Cloning and expression in Escherichia coli of a yeast mannosyltransferase from the asparagine-linked glycosylation pathway | journal = J. Biol. Chem. | volume = 259 | issue = 1 | pages = 378–82 |date=January 1984 | doi = 10.1016/S0021-9258(17)43670-2 | pmid = 6368538 | doi-access = free }}
• {{cite journal | vauthors = Gao XD, Nishikawa A, Dean N | title = Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum | journal = Glycobiology | volume = 14 | issue = 6 | pages = 559–70 |date=June 2004 | pmid = 15044395 | doi = 10.1093/glycob/cwh072 | doi-access = free }}
• {{cite journal | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res.|pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |volume=12 |issue=2|display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Kranz C, Denecke J, Lehle L |title=Congenital Disorder of Glycosylation Type Ik (CDG-Ik): A Defect of Mannosyltransferase I |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 545–51 |year= 2004 |pmid= 14973782 |doi= 10.1086/382493 | pmc=1182267 |display-authors=etal}}
• {{cite journal | vauthors=Schwarz M, Thiel C, Lübbehusen J |title=Deficiency of GDP-Man:GlcNAc2-PP-Dolichol Mannosyltransferase Causes Congenital Disorder of Glycosylation Type Ik |journal=Am. J. Hum. Genet. |volume=74 |issue= 3 |pages= 472–81 |year= 2004 |pmid= 14973778 |doi= 10.1086/382492 | pmc=1182261 |display-authors=etal}}
• {{cite journal | vauthors=Grubenmann CE, Frank CG, Hülsmeier AJ |title=Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik |journal=Hum. Mol. Genet. |volume=13 |issue= 5 |pages= 535–42 |year= 2004 |pmid= 14709599 |doi= 10.1093/hmg/ddh050 |display-authors=etal|doi-access=free |hdl=20.500.11850/51881 |hdl-access=free }}
• {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}

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• [https://www.ncbi.nlm.nih.gov/books/NBK1332/ GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
• {{UCSC gene info|ALG1}}

{{Glycosyltransferases}}