ALOX15B

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase. 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid. The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

• Arachidonate 15-lipoxygenase
• 15-hydroxyicosatetraenoic acid
• ALOX15

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• {{UCSC gene info|ALOX15B}}

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• {{cite journal | vauthors = Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS | title = Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related | journal = The Journal of Biological Chemistry | volume = 265 | issue = 9 | pages = 5113–20 | date = Mar 1990 | doi = 10.1016/S0021-9258(19)34092-X | pmid = 2318885 | doi-access = free }}
• {{cite journal | vauthors = Kilty I, Logan A, Vickers PJ | title = Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase | journal = European Journal of Biochemistry | volume = 266 | issue = 1 | pages = 83–93 | date = Nov 1999 | pmid = 10542053 | doi = 10.1046/j.1432-1327.1999.00818.x | doi-access = free }}
• {{cite journal | vauthors = Krieg P, Marks F, Fürstenberger G | title = A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression | journal = Genomics | volume = 73 | issue = 3 | pages = 323–30 | date = May 2001 | pmid = 11350124 | doi = 10.1006/geno.2001.6519 }}
• {{cite journal | vauthors = Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, Liu J, Chandra D, Traag J, Klein RD, Fischer SM, Chopra D, Shen J, Zhau HE, Chung LW, Tang DG | title = Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 16189–201 | date = May 2002 | pmid = 11839751 | doi = 10.1074/jbc.M111936200 | doi-access = free }}
• {{cite journal | vauthors = Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM | title = Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398 | journal = Neoplasia | volume = 5 | issue = 2 | pages = 121–7 | year = 2003 | pmid = 12659684 | pmc = 1502398 | doi = 10.1016/s1476-5586(03)80003-9 }}
• {{cite journal | vauthors = Bhatia B, Maldonado CJ, Tang S, Chandra D, Klein RD, Chopra D, Shappell SB, Yang P, Newman RA, Tang DG | title = Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants | journal = The Journal of Biological Chemistry | volume = 278 | issue = 27 | pages = 25091–100 | date = Jul 2003 | pmid = 12704195 | doi = 10.1074/jbc.M301920200 | doi-access = free }}
• {{cite journal | vauthors = Tang S, Bhatia B, Zhou J, Maldonado CJ, Chandra D, Kim E, Fischer SM, Butler AP, Friedman SL, Tang DG | title = Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells | journal = Oncogene | volume = 23 | issue = 41 | pages = 6942–53 | date = Sep 2004 | pmid = 15247906 | doi = 10.1038/sj.onc.1207913 | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
• {{cite journal | vauthors = Limor R, Kaplan M, Sawamura T, Sharon O, Keidar S, Weisinger G, Knoll E, Naidich M, Stern N | title = Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway | journal = American Journal of Hypertension | volume = 18 | issue = 3 | pages = 299–307 | date = Mar 2005 | pmid = 15797645 | doi = 10.1016/j.amjhyper.2004.09.008 | doi-access = free }}
• {{cite journal | vauthors = Subbarayan V, Xu XC, Kim J, Yang P, Hoque A, Sabichi AL, Llansa N, Mendoza G, Logothetis CJ, Newman RA, Lippman SM, Menter DG | title = Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia | journal = Neoplasia | volume = 7 | issue = 3 | pages = 280–93 | date = Mar 2005 | pmid = 15799828 | pmc = 1501140 | doi = 10.1593/neo.04457 }}
• {{cite journal | vauthors = Jiang WG, Watkins G, Douglas-Jones A, Mansel RE | title = Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer | journal = Prostaglandins, Leukotrienes, and Essential Fatty Acids | volume = 74 | issue = 4 | pages = 235–45 | date = Apr 2006 | pmid = 16556493 | doi = 10.1016/j.plefa.2006.01.009 }}
• {{cite journal | vauthors = Subbarayan V, Krieg P, Hsi LC, Kim J, Yang P, Sabichi AL, Llansa N, Mendoza G, Logothetis CJ, Newman RA, Lippman SM, Menter DG | title = 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma | journal = Oncogene | volume = 25 | issue = 44 | pages = 6015–25 | date = Sep 2006 | pmid = 16682954 | doi = 10.1038/sj.onc.1209617 | doi-access = free }}
• {{cite journal | vauthors = Lesueur F, Bouadjar B, Lefèvre C, Jobard F, Audebert S, Lakhdar H, Martin L, Tadini G, Karaduman A, Emre S, Saker S, Lathrop M, Fischer J | title = Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13 | journal = The Journal of Investigative Dermatology | volume = 127 | issue = 4 | pages = 829–34 | date = Apr 2007 | pmid = 17139268 | doi = 10.1038/sj.jid.5700640 | doi-access = free }}

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{{Monooxygenases}}

{{Enzymes}}

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Category:EC 1.13.11

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