AMFR
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.{{cite journal | vauthors = Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A | title = Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor | journal = J Biol Chem | volume = 266 | issue = 20 | pages = 13442–8 |date=Aug 1991 | doi = 10.1016/S0021-9258(18)98859-9 | pmid = 1649192 | doi-access = free }}{{cite web | title = Entrez Gene: AMFR autocrine motility factor receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=267}}
Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.
Interactions
AMFR has been shown to interact with Valosin-containing protein.{{cite journal |last=Zhong |first=Xiaoyan |author2=Shen Yuxian |author3=Ballar Petek |author4=Apostolou Andria |author5=Agami Reuven |author6=Fang Shengyun |date=Oct 2004 |title=AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation |journal=J. Biol. Chem. |volume=279 |issue=44 |pages=45676–84 |location = United States| issn = 0021-9258| pmid = 15331598 |doi = 10.1074/jbc.M409034200 |doi-access=free }}{{cite journal |last=Lee |first=Joon No |author2=Zhang Xiangyu |author3=Feramisco Jamison D |author4=Gong Yi |author5=Ye Jin |date=Nov 2008 |title=Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step |journal=J. Biol. Chem. |volume=283 |issue=48 |pages=33772–83 |location = United States| issn = 0021-9258| pmid = 18835813 |doi = 10.1074/jbc.M806108200 |pmc=2586246 |doi-access=free }}
References
{{reflist}}
External links
- {{UCSC gene info|AMFR}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Huang B, Xie Y, Raz A |title=Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 3 |pages= 727–42 |year= 1995 |pmid= 7626106 |doi=10.1006/bbrc.1995.2031 }}
- {{cite journal | vauthors=Hillier LD, Lennon G, Becker M |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Shimizu K, Tani M, Watanabe H |title=The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 295–300 |year= 1999 |pmid= 10456327 |doi=10.1016/S0014-5793(99)00966-7 |s2cid=39270348 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Fang S, Ferrone M, Yang C |title=The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14422–7 |year= 2002 |pmid= 11724934 |doi= 10.1073/pnas.251401598 | pmc=64697 |display-authors=etal|bibcode=2001PNAS...9814422F |doi-access=free }}
- {{cite journal | vauthors=Luo Y, Long JM, Lu C |title=A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. |journal=J. Neurochem. |volume=80 |issue= 2 |pages= 354–61 |year= 2002 |pmid= 11902125 |doi=10.1046/j.0022-3042.2001.00707.x |s2cid=29857457 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Tímár J, Rásó E, Döme B |title=Expression and function of the AMF receptor by human melanoma in experimental and clinical systems. |journal=Clin. Exp. Metastasis |volume=19 |issue= 3 |pages= 225–32 |year= 2002 |pmid= 12067203 |doi=10.1023/A:1015595708241 |s2cid=453423 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Liang JS, Kim T, Fang S |title=Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23984–8 |year= 2003 |pmid= 12670940 |doi= 10.1074/jbc.M302683200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Takanami I, Takeuchi K |title=Autocrine motility factor-receptor gene expression in lung cancer. |journal=Jpn. J. Thorac. Cardiovasc. Surg. |volume=51 |issue= 8 |pages= 368–73 |year= 2003 |pmid= 12962414 |doi=10.1007/BF02719469 }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Registre M, Goetz JG, St Pierre P |title=The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 4 |pages= 1316–22 |year= 2004 |pmid= 15303277 |doi=10.1016/j.bbrc.2004.06.089 |display-authors=etal}}
- {{cite journal | vauthors=Zhong X, Shen Y, Ballar P |title=AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45676–84 |year= 2004 |pmid= 15331598 |doi= 10.1074/jbc.M409034200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Song BL, Sever N, DeBose-Boyd RA |title=Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. |journal=Mol. Cell |volume=19 |issue= 6 |pages= 829–40 |year= 2005 |pmid= 16168377 |doi= 10.1016/j.molcel.2005.08.009 |doi-access= free }}
- {{cite journal | vauthors=Kaynak K, Kara M, Oz B |title=Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas. |journal=Acta Chir. Belg. |volume=105 |issue= 4 |pages= 378–82 |year= 2006 |pmid= 16184720 |doi= 10.1080/00015458.2005.11679740|s2cid=3032480 |display-authors=etal}}
- {{cite journal | vauthors=Ye Y, Shibata Y, Kikkert M |title=Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 40 |pages= 14132–8 |year= 2006 |pmid= 16186510 |doi= 10.1073/pnas.0505006102 | pmc=1242302 |display-authors=etal|bibcode=2005PNAS..10214132Y |doi-access=free }}
- {{cite journal | vauthors=Chen B, Mariano J, Tsai YC |title=The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 2 |pages= 341–6 |year= 2006 |pmid= 16407162 |doi= 10.1073/pnas.0506618103 | pmc=1326157 |display-authors=etal|bibcode=2006PNAS..103..341C |doi-access=free }}
- {{cite journal | vauthors=Haga A, Tanaka N, Funasaka T |title=The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF. |journal=J. Mol. Biol. |volume=358 |issue= 3 |pages= 741–53 |year= 2006 |pmid= 16563432 |doi= 10.1016/j.jmb.2006.02.046 |display-authors=etal}}
- {{cite journal | vauthors=Shen Y, Ballar P, Fang S |title=Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 4 |pages= 1285–93 |year= 2006 |pmid= 16979136 |doi= 10.1016/j.bbrc.2006.08.173 }}
{{refend}}