ANAPC7

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.

ANAPC7 has been shown to interact with ANAPC1,{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Curr. Biol. | volume = 13 | issue = 17 | pages = 1459–68 |date=September 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 | s2cid = 5942532 | doi-access = free | bibcode = 2003CBio...13.1459V }}{{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = J. Cell Biol. | volume = 151 | issue = 4 | pages = 749–62 |date=November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749 }} ANAPC4, CDC27{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 16 | pages = 8973–8 |date=August 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 | bibcode = 2000PNAS...97.8973G | doi-access = free }} and CDC20.{{cite journal | vauthors = Nilsson J, Yekezare M, Minshull J, Pines J | title = The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | journal = Nat. Cell Biol. | volume = 10 | issue = 12 | pages = 1411–20 |date=December 2008 | pmid = 18997788 | pmc = 2635557 | doi = 10.1038/ncb1799 }}

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• {{UCSC gene info|ANAPC7}}

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• {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
• {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
• {{cite journal | vauthors=Yu H, Peters JM, King RW |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=10.1126/science.279.5354.1219 |bibcode=1998Sci...279.1219Y |display-authors=etal}}
• {{cite journal | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Chan GK, Jablonski SA, Sudakin V |title=Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941–54 |year= 1999 |pmid= 10477750 |doi=10.1083/jcb.146.5.941 | pmc=2169490 |display-authors=etal}}
• {{cite journal | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317 | pmc=18031 |bibcode=1999PNAS...9611317G |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973 | pmc=16806 |bibcode=2000PNAS...97.8973G |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5 |s2cid=5942532 |display-authors=etal|doi-access=free |bibcode=2003CBio...13.1459V }}
• {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Park KH, Choi SE, Eom M, Kang Y |title=Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships |journal=Breast Cancer Res. |volume=7 |issue= 2 |pages= R238–47 |year= 2006 |pmid= 15743504 |doi= 10.1186/bcr978 | pmc=1064132 |doi-access=free }}
• {{cite journal | vauthors=Turnell AS, Stewart GS, Grand RJ |title=The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression |journal=Nature |volume=438 |issue= 7068 |pages= 690–5 |year= 2005 |pmid= 16319895 |doi= 10.1038/nature04151 |bibcode=2005Natur.438..690T |s2cid=4432156 |display-authors=etal}}

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