ANGPT2

• See Angiopoietin#Clinical relevance

ANGPT2 has been shown to interact with TEK tyrosine kinase.{{cite journal | vauthors = Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG | title = Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1721–7 | date = January 2003 | pmid = 12427764 | doi = 10.1074/jbc.M208550200 | doi-access = free }}{{cite journal | vauthors = Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = International Immunology | volume = 10 | issue = 8 | pages = 1217–27 | date = August 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 | doi-access = free }}{{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | date = July 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 }}

• Angiopoietin

{{reflist}}

• {{UCSC gene info|ANGPT2}}

{{refbegin | 2}}

• {{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | date = July 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 }}
• {{cite journal | vauthors = Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = International Immunology | volume = 10 | issue = 8 | pages = 1217–27 | date = August 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 | doi-access = free }}
• {{cite journal | vauthors = Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR | title = Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma | journal = The Journal of Clinical Investigation | volume = 103 | issue = 3 | pages = 341–5 | date = February 1999 | pmid = 9927494 | pmc = 407900 | doi = 10.1172/JCI4891 }}
• {{cite journal | vauthors = Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD | title = Angiopoietins 3 and 4: diverging gene counterparts in mice and humans | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 1904–9 | date = March 1999 | pmid = 10051567 | pmc = 26709 | doi = 10.1073/pnas.96.5.1904 | bibcode = 1999PNAS...96.1904V | doi-access = free }}
• {{cite journal | vauthors = Grosios K, Leek JP, Markham AF, Yancopoulos GD, Jones PF | title = Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1–2 | pages = 118–20 | year = 1999 | pmid = 10343124 | doi = 10.1159/000015235 | s2cid = 40232421 }}
• {{cite journal | vauthors = Procopio WN, Pelavin PI, Lee WM, Yeilding NM | title = Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 42 | pages = 30196–201 | date = October 1999 | pmid = 10514510 | doi = 10.1074/jbc.274.42.30196 | doi-access = free }}
• {{cite journal | vauthors = Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY | title = Characterization and expression of a novel alternatively spliced human angiopoietin-2 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18550–6 | date = June 2000 | pmid = 10766762 | doi = 10.1074/jbc.M910084199 | doi-access = free }}
• {{cite journal | vauthors = Mezquita J, Mezquita P, Montserrat P, Mezquita B, Francone V, Vilagrasa X, Mezquita C | title = Genomic structure and alternative splicing of chicken angiopoietin-2 | journal = Biochemical and Biophysical Research Communications | volume = 275 | issue = 2 | pages = 643–51 | date = August 2000 | pmid = 10964717 | doi = 10.1006/bbrc.2000.3345 }}
• {{cite journal | vauthors = Xu Y, Yu Q | title = Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region | journal = The Journal of Biological Chemistry | volume = 276 | issue = 37 | pages = 34990–8 | date = September 2001 | pmid = 11447223 | doi = 10.1074/jbc.M103661200 | doi-access = free }}
• {{cite journal | vauthors = Acker T, Beck H, Plate KH | title = Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization | journal = Mechanisms of Development | volume = 108 | issue = 1–2 | pages = 45–57 | date = October 2001 | pmid = 11578860 | doi = 10.1016/S0925-4773(01)00471-3 | s2cid = 18841951 | doi-access = free }}
• {{cite journal | vauthors = Ward EG, Grosios K, Markham AF, Jones PF | title = Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2 | journal = Cytogenetics and Cell Genetics | volume = 94 | issue = 3–4 | pages = 147–54 | year = 2002 | pmid = 11856872 | doi = 10.1159/000048807 | s2cid = 22445942 }}
• {{cite journal | vauthors = Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S | title = Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells | journal = Blood | volume = 99 | issue = 5 | pages = 1646–50 | date = March 2002 | pmid = 11861279 | doi = 10.1182/blood.V99.5.1646 | doi-access = free }}
• {{cite journal | vauthors = Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K | title = Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer | journal = Oncology | volume = 62 | issue = 4 | pages = 340–8 | year = 2002 | pmid = 12138242 | doi = 10.1159/000065066 | s2cid = 40689314 }}
• {{cite journal | vauthors = Lin S, Shyu KG, Lee CC, Wang BW, Chang CC, Liu YC, Huang FY, Chang H | title = Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 3 | pages = 710–5 | date = August 2002 | pmid = 12176040 | doi = 10.1016/S0006-291X(02)00924-5 }}
• {{cite journal | vauthors = Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB | title = Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2 | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 9 | pages = 4213–24 | date = September 2002 | pmid = 12213874 | doi = 10.1210/jc.2002-020195 | doi-access = free }}
• {{cite journal | vauthors = Paradis V, Bièche I, Dargère D, Laurendeau I, Nectoux J, Degott C, Belghiti J, Vidaud M, Bedossa P | title = A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia | journal = Gastroenterology | volume = 124 | issue = 3 | pages = 651–9 | date = March 2003 | pmid = 12612904 | doi = 10.1053/gast.2003.50104 | doi-access = free }}

{{refend}}

{{PDB Gallery|geneid=285}}

{{NLM content}}

{{Antiangiogenics}}

{{Angiogenic proteins}}

{{Growth factor receptor modulators}}

{{gene-8-stub}}