ANP32E

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.{{cite journal |vauthors=Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y | title = Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain | journal = Cytogenet Genome Res | volume = 97 | issue = 1–2 | pages = 68–71 |date=Nov 2002 | pmid = 12438741 | doi =10.1159/000064058 | s2cid = 30549428 }}{{cite web | title = Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81611}} The ANP32E gene is located on chromosome 1q22. In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.{{cite journal |vauthors=Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A | title = ANP32E is a histone chaperone that removes H2A.Z from chromatin | journal = Nature | volume = 505 | issue = 7485 | pages = 648–53 | year = 2014 | pmid = 24463511 | doi = 10.1038/nature12922 | bibcode = 2014Natur.505..648O | s2cid = 4406370 }} In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis{{cite journal |vauthors=Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M | title = Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis | journal = Eur. J. Neurosci. | volume = 23 | issue = 2 | pages = 309–24 | year = 2006 | pmid = 16420440 | doi = 10.1111/j.1460-9568.2005.04555.x | s2cid = 46587416 }} and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.{{cite journal |author=Santa-Coloma |first=T.A. |year=2003 |title=Anp32e (Cpd1) and related protein phosphatase 2 inhibitors |journal=Cerebellum |volume=2 |issue=4 |pages=310–20 |doi=10.1080/14734220310017212 |pmid=14964690 |s2cid=21454532}}