AP1M1

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.{{cite web | title = Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8907}}

AP1M1 has been shown to interact with VAMP4{{cite journal | vauthors = Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA | title = AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 | journal = EMBO Reports | volume = 4 | issue = 12 | pages = 1182–9 | date = Dec 2003 | pmid = 14608369 | pmc = 1326413 | doi = 10.1038/sj.embor.7400018 }} and AP1G1.{{cite journal | vauthors = Fölsch H, Ohno H, Bonifacino JS, Mellman I | title = A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells | journal = Cell | volume = 99 | issue = 2 | pages = 189–98 | date = Oct 1999 | pmid = 10535737 | doi = 10.1016/S0092-8674(00)81650-5 | s2cid = 15288582 | doi-access = free }}{{cite journal | vauthors = Page LJ, Robinson MS | title = Targeting signals and subunit interactions in coated vesicle adaptor complexes | journal = The Journal of Cell Biology | volume = 131 | issue = 3 | pages = 619–30 | date = Nov 1995 | pmid = 7593184 | pmc = 2120623 | doi = 10.1083/jcb.131.3.619 }}

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• {{cite journal | vauthors = Geyer M, Fackler OT, Peterlin BM | title = Structure--function relationships in HIV-1 Nef | journal = EMBO Reports | volume = 2 | issue = 7 | pages = 580–5 | date = Jul 2001 | pmid = 11463741 | pmc = 1083955 | doi = 10.1093/embo-reports/kve141 }}
• {{cite journal | vauthors = Bénichou S, Benmerah A | title = [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] | journal = Médecine/Sciences | volume = 19 | issue = 1 | pages = 100–6 | date = Jan 2003 | pmid = 12836198 | doi = 10.1051/medsci/2003191100 | doi-access = free }}
• {{cite journal | vauthors = Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS | title = Interaction of tyrosine-based sorting signals with clathrin-associated proteins | journal = Science | volume = 269 | issue = 5232 | pages = 1872–5 | date = Sep 1995 | pmid = 7569928 | doi = 10.1126/science.7569928 | bibcode = 1995Sci...269.1872O }}
• {{cite journal | vauthors = Page LJ, Robinson MS | title = Targeting signals and subunit interactions in coated vesicle adaptor complexes | journal = The Journal of Cell Biology | volume = 131 | issue = 3 | pages = 619–30 | date = Nov 1995 | pmid = 7593184 | pmc = 2120623 | doi = 10.1083/jcb.131.3.619 }}
• {{cite journal | vauthors = Seaman MN, Sowerby PJ, Robinson MS | title = Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25446–51 | date = Oct 1996 | pmid = 8810314 | doi = 10.1074/jbc.271.41.25446 | doi-access = free }}
• {{cite journal | vauthors = Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D | title = The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane | journal = Immunity | volume = 6 | issue = 1 | pages = 67–77 | date = Jan 1997 | pmid = 9052838 | doi = 10.1016/S1074-7613(00)80243-5 | doi-access = free }}
• {{cite journal | vauthors = Foti M, Mangasarian A, Piguet V, Lew DP, Krause KH, Trono D, Carpentier JL | title = Nef-mediated clathrin-coated pit formation | journal = The Journal of Cell Biology | volume = 139 | issue = 1 | pages = 37–47 | date = Oct 1997 | pmid = 9314527 | pmc = 2139808 | doi = 10.1083/jcb.139.1.37 }}
• {{cite journal | vauthors = Ohno H, Aguilar RC, Fournier MC, Hennecke S, Cosson P, Bonifacino JS | title = Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family | journal = Virology | volume = 238 | issue = 2 | pages = 305–15 | date = Nov 1997 | pmid = 9400603 | doi = 10.1006/viro.1997.8839 | doi-access = free }}
• {{cite journal | vauthors = Piguet V, Chen YL, Mangasarian A, Foti M, Carpentier JL, Trono D | title = Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes | journal = The EMBO Journal | volume = 17 | issue = 9 | pages = 2472–81 | date = May 1998 | pmid = 9564030 | pmc = 1170589 | doi = 10.1093/emboj/17.9.2472 }}
• {{cite journal | vauthors = Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O | title = Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules | journal = Immunity | volume = 8 | issue = 4 | pages = 483–95 | date = Apr 1998 | pmid = 9586638 | doi = 10.1016/S1074-7613(00)80553-1 | doi-access = free }}
• {{cite journal | vauthors = Craig HM, Pandori MW, Guatelli JC | title = Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11229–34 | date = Sep 1998 | pmid = 9736718 | pmc = 21624 | doi = 10.1073/pnas.95.19.11229 | bibcode = 1998PNAS...9511229C | doi-access = free }}
• {{cite journal | vauthors = Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC | title = A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor | journal = Current Biology | volume = 8 | issue = 22 | pages = 1235–8 | date = Nov 1998 | pmid = 9811606 | doi = 10.1016/S0960-9822(07)00517-9 | s2cid = 16541580 | doi-access = free | bibcode = 1998CBio....8.1235B }}
• {{cite journal | vauthors = Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T | title = A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 | journal = Current Biology | volume = 8 | issue = 22 | pages = 1239–42 | date = Nov 1998 | pmid = 9811611 | doi = 10.1016/S0960-9822(07)00518-0 | s2cid = 14272751 | doi-access = free | bibcode = 1998CBio....8.1239G }}
• {{cite journal | vauthors = Owen DJ, Evans PR | title = A structural explanation for the recognition of tyrosine-based endocytotic signals | journal = Science | volume = 282 | issue = 5392 | pages = 1327–32 | date = Nov 1998 | pmid = 9812899 | pmc = 5600252 | doi = 10.1126/science.282.5392.1327 | bibcode = 1998Sci...282.1327O }}
• {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi = 10.1128/JVI.73.2.1350-1361.1999}}
• {{cite journal | vauthors = Fölsch H, Ohno H, Bonifacino JS, Mellman I | title = A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells | journal = Cell | volume = 99 | issue = 2 | pages = 189–98 | date = Oct 1999 | pmid = 10535737 | doi = 10.1016/S0092-8674(00)81650-5 | s2cid = 15288582 | doi-access = free }}
• {{cite journal | vauthors = Orzech E, Cohen S, Weiss A, Aroeti B | title = Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 15207–19 | date = May 2000 | pmid = 10809756 | doi = 10.1074/jbc.275.20.15207 | doi-access = free }}
• {{cite journal | vauthors = Umeda A, Meyerholz A, Ungewickell E | title = Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation | journal = European Journal of Cell Biology | volume = 79 | issue = 5 | pages = 336–42 | date = May 2000 | pmid = 10887964 | doi = 10.1078/S0171-9335(04)70037-0 }}
• {{cite journal | vauthors = Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N | title = A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex | journal = Cell | volume = 103 | issue = 4 | pages = 569–81 | date = Nov 2000 | pmid = 11106728 | doi = 10.1016/S0092-8674(00)00161-6 | s2cid = 18245989 | doi-access = free }}

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• {{UCSC gene info|AP1M1}}

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