AP3D1

AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]

AP3D1 has been shown to interact with SYBL1.{{cite journal | vauthors = Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T | title = A dual mechanism controlling the localization and function of exocytic v-SNAREs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 15 | pages = 9011–6 | date = Jul 2003 | pmid = 12853575 | pmc = 166429 | doi = 10.1073/pnas.1431910100 | bibcode = 2003PNAS..100.9011M | doi-access = free }}

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• {{UCSC gene info|AP3D1}}

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• {{cite journal | vauthors = Höning S, Sandoval IV, von Figura K | title = A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3 | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1304–14 | date = Aug 1998 | pmid = 9482728 | pmc = 1170479 | doi = 10.1093/emboj/17.5.1304 }}
• {{cite journal | vauthors = Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M | title = Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles | journal = Neuron | volume = 21 | issue = 1 | pages = 111–22 | date = Jul 1998 | pmid = 9697856 | doi = 10.1016/S0896-6273(00)80519-X | s2cid = 17237941 | doi-access = free }}
• {{cite journal | vauthors = Rehling P, Darsow T, Katzmann DJ, Emr SD | title = Formation of AP-3 transport intermediates requires Vps41 function | journal = Nature Cell Biology | volume = 1 | issue = 6 | pages = 346–53 | year = 2000 | pmid = 10559961 | doi = 10.1038/14037 | s2cid = 24932376 }}
• {{cite journal | vauthors = Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC | title = Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif | journal = Virology | volume = 271 | issue = 1 | pages = 9–17 | date = May 2000 | pmid = 10814565 | doi = 10.1006/viro.2000.0277 | doi-access = free }}
• {{cite journal | vauthors = Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G | title = PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2191–201 | date = May 2001 | pmid = 11331585 | pmc = 125242 | doi = 10.1093/emboj/20.9.2191 }}
• {{cite journal | vauthors = Austin C, Boehm M, Tooze SA | title = Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3 | journal = Biochemistry | volume = 41 | issue = 14 | pages = 4669–77 | date = Apr 2002 | pmid = 11926829 | doi = 10.1021/bi016064j }}
• {{cite journal | vauthors = Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J | title = HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8725–32 | date = Mar 2003 | pmid = 12486136 | doi = 10.1074/jbc.M210115200 | doi-access = free }}
• {{cite journal | vauthors = Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA | title = Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1 | journal = Developmental Cell | volume = 5 | issue = 3 | pages = 513–21 | date = Sep 2003 | pmid = 12967569 | doi = 10.1016/S1534-5807(03)00234-X | doi-access = free }}
• {{cite journal | vauthors = Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V | title = The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation | journal = Molecular Biology of the Cell | volume = 15 | issue = 2 | pages = 575–87 | date = Feb 2004 | pmid = 14657250 | pmc = 329249 | doi = 10.1091/mbc.E03-06-0401 }}
• {{cite journal | vauthors = Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS | title = An ear-core interaction regulates the recruitment of the AP-3 complex to membranes | journal = Developmental Cell | volume = 7 | issue = 4 | pages = 619–25 | date = Oct 2004 | pmid = 15469849 | doi = 10.1016/j.devcel.2004.08.009 | doi-access = free }}
• {{cite journal | vauthors = Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC | title = Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes | journal = Journal of Virology | volume = 79 | issue = 4 | pages = 2066–78 | date = Feb 2005 | pmid = 15681409 | pmc = 546596 | doi = 10.1128/JVI.79.4.2066-2078.2005 }}
• {{cite journal | vauthors = Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P | title = AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly | journal = Cell | volume = 120 | issue = 5 | pages = 663–74 | date = Mar 2005 | pmid = 15766529 | doi = 10.1016/j.cell.2004.12.023 | s2cid = 14528434 | doi-access = free }}
• {{cite journal | vauthors = Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G | title = Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes | journal = Molecular Biology of the Cell | volume = 16 | issue = 11 | pages = 5356–72 | year = 2006 | pmid = 16162817 | pmc = 1266432 | doi = 10.1091/mbc.E05-07-0626 }}

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