ARF3

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns.

ARF3 has been shown to interact with:

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• ARFIP1,{{cite journal | vauthors = Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH | title = Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D | journal = FEBS Lett. | volume = 454 | issue = 1–2 | pages = 85–9 | date = July 1999 | pmid = 10413101 | doi = 10.1016/s0014-5793(99)00771-1| s2cid = 40655171 | doi-access = }}
• ARFIP2,{{cite journal | vauthors = Kanoh H, Williger BT, Exton JH | title = Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes | journal = J. Biol. Chem. | volume = 272 | issue = 9 | pages = 5421–9 | date = February 1997 | pmid = 9038142 | doi = 10.1074/jbc.272.9.5421| doi-access = free}}
• GGA1,
• GGA3,{{cite journal | vauthors = Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O | title = ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization | journal = Mol. Biol. Cell | volume = 13 | issue = 9 | pages = 3078–95 | date = September 2002 | pmid = 12221117 | pmc = 124144 | doi = 10.1091/mbc.E02-02-0078 }}{{cite journal | vauthors = Boman AL, ((Zhang Cj)), Zhu X, Kahn RA | title = A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi | journal = Mol. Biol. Cell | volume = 11 | issue = 4 | pages = 1241–55 | date = April 2000 | pmid = 10749927 | pmc = 14844 | doi = 10.1091/mbc.11.4.1241}} and
• KIF23.{{cite journal | vauthors = Boman AL, Kuai J, Zhu X, Chen J, Kuriyama R, Kahn RA | title = Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion | journal = Cell Motil. Cytoskeleton | volume = 44 | issue = 2 | pages = 119–32 | date = October 1999 | pmid = 10506747 | doi = 10.1002/(SICI)1097-0169(199910)44:2<119::AID-CM4>3.0.CO;2-C }}

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{{reflist}}

• {{UCSC gene info|ARF3}}

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• {{cite journal | vauthors = Lee FJ, Moss J, Vaughan M | title = Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae | journal = J. Biol. Chem. | volume = 267 | issue = 34 | pages = 24441–5 | year = 1992 | doi = 10.1016/S0021-9258(18)35786-7 | pmid = 1447192 | doi-access = free }}
• {{cite journal | vauthors = Lee CM, Haun RS, Tsai SC, Moss J, Vaughan M | title = Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin | journal = J. Biol. Chem. | volume = 267 | issue = 13 | pages = 9028–34 | year = 1992 | doi = 10.1016/S0021-9258(19)50383-0 | pmid = 1577740 | doi-access = free }}
• {{cite journal | vauthors = Tsai SC, Haun RS, Tsuchiya M, Moss J, Vaughan M | title = Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin | journal = J. Biol. Chem. | volume = 266 | issue = 34 | pages = 23053–9 | year = 1991 | doi = 10.1016/S0021-9258(18)54462-8 | pmid = 1744102 | doi-access = free }}
• {{cite journal | vauthors = Stearns T, Willingham MC, Botstein D, Kahn RA | title = ADP-ribosylation factor is functionally and physically associated with the Golgi complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 3 | pages = 1238–42 | year = 1990 | pmid = 2105501 | pmc = 53446 | doi = 10.1073/pnas.87.3.1238 | bibcode = 1990PNAS...87.1238S | doi-access = free }}
• {{cite journal | vauthors = Bobak DA, Nightingale MS, Murtagh JJ, Price SR, Moss J, Vaughan M | title = Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 16 | pages = 6101–5 | year = 1989 | pmid = 2474826 | pmc = 297783 | doi = 10.1073/pnas.86.16.6101 | bibcode = 1989PNAS...86.6101B | doi-access = free }}
• {{cite journal | vauthors = Orcl L, Palmer DJ, Amherdt M, Rothman JE | title = Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol | journal = Nature | volume = 364 | issue = 6439 | pages = 732–4 | year = 1993 | pmid = 8355790 | doi = 10.1038/364732a0 | bibcode = 1993Natur.364..732O | s2cid = 4348442 }}
• {{cite journal | vauthors = Haun RS, Moss J, Vaughan M | title = Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter | journal = J. Biol. Chem. | volume = 268 | issue = 12 | pages = 8793–800 | year = 1993 | doi = 10.1016/S0021-9258(18)52944-6 | pmid = 8473323 | doi-access = free }}
• {{cite journal | vauthors = Helms JB, Palmer DJ, Rothman JE | title = Two distinct populations of ARF bound to Golgi membranes | journal = J. Cell Biol. | volume = 121 | issue = 4 | pages = 751–60 | year = 1993 | pmid = 8491770 | pmc = 2119793 | doi = 10.1083/jcb.121.4.751 }}
• {{cite journal | vauthors = Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K | title = Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6) | journal = J. Biochem. | volume = 120 | issue = 4 | pages = 813–9 | year = 1996 | pmid = 8947846 | doi = 10.1093/oxfordjournals.jbchem.a021484 }}
• {{cite journal | vauthors = Kanoh H, Williger BT, Exton JH | title = Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes | journal = J. Biol. Chem. | volume = 272 | issue = 9 | pages = 5421–9 | year = 1997 | pmid = 9038142 | doi = 10.1074/jbc.272.9.5421 | doi-access = free}}
• {{cite journal | vauthors = Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH | title = Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D | journal = FEBS Lett. | volume = 454 | issue = 1–2 | pages = 85–9 | year = 1999 | pmid = 10413101 | doi = 10.1016/S0014-5793(99)00771-1 | s2cid = 40655171 | doi-access = }}
• {{cite journal | vauthors = Boman AL, Kuai J, Zhu X, Chen J, Kuriyama R, Kahn RA | title = Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion | journal = Cell Motil. Cytoskeleton | volume = 44 | issue = 2 | pages = 119–32 | year = 1999 | pmid = 10506747 | doi = 10.1002/(SICI)1097-0169(199910)44:2<119::AID-CM4>3.0.CO;2-C }}
• {{cite journal | vauthors = Takeya R, Takeshige K, Sumimoto H | title = Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors | journal = Biochem. Biophys. Res. Commun. | volume = 267 | issue = 1 | pages = 149–55 | year = 2000 | pmid = 10623590 | doi = 10.1006/bbrc.1999.1932 }}
• {{cite journal | vauthors = Boman AL, ((Zhang Cj)), Zhu X, Kahn RA | title = A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi | journal = Mol. Biol. Cell | volume = 11 | issue = 4 | pages = 1241–55 | year = 2000 | pmid = 10749927 | pmc = 14844 | doi = 10.1091/mbc.11.4.1241 }}
• {{cite journal | vauthors = Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M | title = Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16827–36 | year = 2000 | pmid = 10828067 | doi = 10.1074/jbc.275.22.16827 | doi-access = free }}
• {{cite journal | vauthors = Zhdankina O, Strand NL, Redmond JM, Boman AL | title = Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi | journal = Yeast | volume = 18 | issue = 1 | pages = 1–18 | year = 2001 | pmid = 11124697 | doi = 10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5 | s2cid = 10348751 | doi-access = free }}
• {{cite journal | vauthors = Irobi J, Nelis E, Verhoeven K, De Vriendt E, Dierick I, De Jonghe P, Van Broeckhoven C, Timmerman V | title = Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3 | journal = J. Peripher. Nerv. Syst. | volume = 7 | issue = 2 | pages = 87–95 | year = 2002 | pmid = 12090300 | doi = 10.1046/j.1529-8027.2002.02014.x | s2cid = 8453412 }}
• {{cite journal | vauthors = Li F, Mandal M, Mishra SK, Barnes CJ, Kumar R | title = Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3 | journal = FEBS Lett. | volume = 524 | issue = 1–3 | pages = 49–53 | year = 2002 | pmid = 12135740 | doi = 10.1016/S0014-5793(02)02994-0 | s2cid = 36764648 }}
• {{cite journal | vauthors = Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O | title = ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization | journal = Mol. Biol. Cell | volume = 13 | issue = 9 | pages = 3078–95 | year = 2002 | pmid = 12221117 | pmc = 124144 | doi = 10.1091/mbc.E02-02-0078 }}

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