ARHGAP4
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.{{cite journal | vauthors = Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P | title = An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 2 | pages = 695–9 |date=Mar 1996 | pmid = 8570618 | pmc = 40115 | doi =10.1073/pnas.93.2.695 | bibcode = 1996PNAS...93..695T | doi-access = free }}{{cite web | title = Entrez Gene: ARHGAP4 Rho GTPase activating protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=393| accessdate = }} It has been shown to regulate cell motility and axonal outgrowth in vitro.{{cite journal | last1 = Vogt | first1 = DL | last2 = Gray | first2 = CD | last3 = Young Ws | first3 = 3rd | last4 = Orellana | first4 = SA | last5 = Malouf | first5 = AT | title = ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth | journal = Molecular and Cellular Neurosciences | volume = 36 | issue = 3 | pages = 332–42 | year = 2007 | pmid = 17804252 | pmc = 2111057 | doi = 10.1016/j.mcn.2007.07.004 }}
References
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External links
- {{UCSC gene info|ARHGAP4}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Tribioli C, Mancini M, Plassart E |title=Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae |journal=Hum. Mol. Genet. |volume=3 |issue= 7 |pages= 1061–7 |year= 1995 |pmid= 7981673 |doi=10.1093/hmg/3.7.1061 |display-authors=etal}}
- {{cite journal | vauthors=Nagase T, Seki N, Tanaka A |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=10.1093/dnares/2.4.167 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse |journal=Genomics |volume=44 |issue= 1 |pages= 8–14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
- {{cite journal | vauthors=Zuber J, Tchernitsa OI, Hinzmann B |title=A genome-wide survey of RAS transformation targets |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144–52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799 |s2cid=21887748 |display-authors=etal}}
- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
- {{cite journal | vauthors=Demura M, Takeda Y, Yoneda T |title=Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus |journal=Hum. Mutat. |volume=19 |issue= 1 |pages= 23–9 |year= 2002 |pmid= 11754100 |doi= 10.1002/humu.10011 |s2cid=21379792 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Christerson LB, Gallagher E, Vanderbilt CA |title=p115 Rho GTPase activating protein interacts with MEKK1 |journal=J. Cell. Physiol. |volume=192 |issue= 2 |pages= 200–8 |year= 2002 |pmid= 12115726 |doi= 10.1002/jcp.10125 |s2cid=33717402 |display-authors=etal}}
- {{cite journal | vauthors=Foletta VC, Brown FD, Young WS |title=Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules |journal=Brain Res. Mol. Brain Res. |volume=107 |issue= 1 |pages= 65–79 |year= 2003 |pmid= 12414125 |doi=10.1016/S0169-328X(02)00448-5 |url=https://zenodo.org/record/1259925 }}
- {{cite journal | vauthors=Soderling SH, Binns KL, Wayman GA |title=The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 970–5 |year= 2003 |pmid= 12447388 |doi= 10.1038/ncb886 |s2cid=1423222 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Katoh M, Katoh M |title=FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 791–7 |year= 2004 |pmid= 12736724 |doi= 10.3892/ijmm.11.6.791}}
- {{cite journal | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
- {{cite journal | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
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