ARHGAP5

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.

ARHGAP5 has been shown to interact with Rnd1,{{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Curr. Biol. | volume = 13 | issue = 13 | pages = 1106–15 | date = Jul 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 | pmc = 6918695 }} Rnd2, Rnd3 and RHOA.

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• {{UCSC gene info|ARHGAP5}}

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• {{cite journal | vauthors = Ellis C, Moran M, McCormick F, Pawson T | title = Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases | journal = Nature | volume = 343 | issue = 6256 | pages = 377–81 | year = 1990 | pmid = 1689011 | doi = 10.1038/343377a0 | bibcode = 1990Natur.343..377E | hdl = 1807/9436 | s2cid = 4350408 | hdl-access = free }}
• {{cite journal | vauthors = Foster R, Hu KQ, Shaywitz DA, Settleman J | title = p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly | journal = Mol. Cell. Biol. | volume = 14 | issue = 11 | pages = 7173–81 | year = 1994 | pmid = 7935432 | pmc = 359251 | doi = 10.1128/mcb.14.11.7173}}
• {{cite journal | vauthors = McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T | title = The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion | journal = EMBO J. | volume = 12 | issue = 8 | pages = 3073–81 | year = 1993 | pmid = 8344248 | pmc = 413572 | doi = 10.1002/j.1460-2075.1993.tb05976.x}}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, Avraham S, Avraham H | title = RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion | journal = Oncogene | volume = 19 | issue = 10 | pages = 1318–28 | year = 2000 | pmid = 10713673 | doi = 10.1038/sj.onc.1203422 | doi-access = free }}
• {{cite journal | vauthors = Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T | title = Role of p120 Ras-GAP in directed cell movement | journal = J. Cell Biol. | volume = 149 | issue = 2 | pages = 457–70 | year = 2000 | pmid = 10769036 | pmc = 2175152 | doi = 10.1083/jcb.149.2.457 }}
• {{cite journal |author6-link=Jeffrey M. Rosen | vauthors = Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM | title = P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer | journal = Cell Growth Differ. | volume = 11 | issue = 7 | pages = 343–54 | year = 2000 | pmid = 10939588 }}
• {{cite journal | vauthors = Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, Ullrich A, Miyazaki H | title = Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone | journal = Mol. Endocrinol. | volume = 17 | issue = 4 | pages = 534–49 | year = 2003 | pmid = 12554790 | doi = 10.1210/me.2002-0187 | doi-access = free }}
• {{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Curr. Biol. | volume = 13 | issue = 13 | pages = 1106–15 | year = 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 | pmc = 6918695 }}
• {{cite journal | vauthors = Su L, Agati JM, Parsons SJ | title = p190RhoGAP is cell cycle regulated and affects cytokinesis | journal = J. Cell Biol. | volume = 163 | issue = 3 | pages = 571–82 | year = 2003 | pmid = 14610059 | pmc = 2173658 | doi = 10.1083/jcb.200308007 }}
• {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
• {{cite journal | vauthors = Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML | title = Substrate-trapping techniques in the identification of cellular PTP targets | journal = Methods | volume = 35 | issue = 1 | pages = 44–53 | year = 2005 | pmid = 15588985 | doi = 10.1016/j.ymeth.2004.07.007 }}
• {{cite journal | vauthors = Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM | title = P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland | journal = Mol. Endocrinol. | volume = 20 | issue = 6 | pages = 1391–405 | year = 2006 | pmid = 16469769 | doi = 10.1210/me.2005-0426 | doi-access = free }}
• {{cite journal | vauthors = Zhan X, Desiderio DM | title = Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry | journal = Anal. Biochem. | volume = 354 | issue = 2 | pages = 279–89 | year = 2006 | pmid = 16777052 | doi = 10.1016/j.ab.2006.05.024 }}

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