ARHGAP5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.{{cite journal | vauthors = Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y | title = p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking | journal = J. Biol. Chem. | volume = 270 | issue = 52 | pages = 30919–26 | year = 1995 | pmid = 8537347 | doi = 10.1074/jbc.270.52.30919 | doi-access = free }}{{cite web | title = Entrez Gene: ARHGAP5 Rho GTPase activating protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=394}}
Function
Interactions
ARHGAP5 has been shown to interact with Rnd1,{{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Curr. Biol. | volume = 13 | issue = 13 | pages = 1106–15 | date = Jul 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 | pmc = 6918695 }} Rnd2, Rnd3 and RHOA.
References
{{reflist}}
External links
- {{UCSC gene info|ARHGAP5}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Ellis C, Moran M, McCormick F, Pawson T | title = Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases | journal = Nature | volume = 343 | issue = 6256 | pages = 377–81 | year = 1990 | pmid = 1689011 | doi = 10.1038/343377a0 | bibcode = 1990Natur.343..377E | hdl = 1807/9436 | s2cid = 4350408 | hdl-access = free }}
- {{cite journal | vauthors = Foster R, Hu KQ, Shaywitz DA, Settleman J | title = p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly | journal = Mol. Cell. Biol. | volume = 14 | issue = 11 | pages = 7173–81 | year = 1994 | pmid = 7935432 | pmc = 359251 | doi = 10.1128/mcb.14.11.7173}}
- {{cite journal | vauthors = McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T | title = The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion | journal = EMBO J. | volume = 12 | issue = 8 | pages = 3073–81 | year = 1993 | pmid = 8344248 | pmc = 413572 | doi = 10.1002/j.1460-2075.1993.tb05976.x}}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, Avraham S, Avraham H | title = RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion | journal = Oncogene | volume = 19 | issue = 10 | pages = 1318–28 | year = 2000 | pmid = 10713673 | doi = 10.1038/sj.onc.1203422 | doi-access = free }}
- {{cite journal | vauthors = Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T | title = Role of p120 Ras-GAP in directed cell movement | journal = J. Cell Biol. | volume = 149 | issue = 2 | pages = 457–70 | year = 2000 | pmid = 10769036 | pmc = 2175152 | doi = 10.1083/jcb.149.2.457 }}
- {{cite journal |author6-link=Jeffrey M. Rosen | vauthors = Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM | title = P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer | journal = Cell Growth Differ. | volume = 11 | issue = 7 | pages = 343–54 | year = 2000 | pmid = 10939588 }}
- {{cite journal | vauthors = Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, Ullrich A, Miyazaki H | title = Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone | journal = Mol. Endocrinol. | volume = 17 | issue = 4 | pages = 534–49 | year = 2003 | pmid = 12554790 | doi = 10.1210/me.2002-0187 | doi-access = free }}
- {{cite journal | vauthors = Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH | title = Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | journal = Curr. Biol. | volume = 13 | issue = 13 | pages = 1106–15 | year = 2003 | pmid = 12842009 | doi = 10.1016/S0960-9822(03)00418-4 | pmc = 6918695 }}
- {{cite journal | vauthors = Su L, Agati JM, Parsons SJ | title = p190RhoGAP is cell cycle regulated and affects cytokinesis | journal = J. Cell Biol. | volume = 163 | issue = 3 | pages = 571–82 | year = 2003 | pmid = 14610059 | pmc = 2173658 | doi = 10.1083/jcb.200308007 }}
- {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
- {{cite journal | vauthors = Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML | title = Substrate-trapping techniques in the identification of cellular PTP targets | journal = Methods | volume = 35 | issue = 1 | pages = 44–53 | year = 2005 | pmid = 15588985 | doi = 10.1016/j.ymeth.2004.07.007 }}
- {{cite journal | vauthors = Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM | title = P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland | journal = Mol. Endocrinol. | volume = 20 | issue = 6 | pages = 1391–405 | year = 2006 | pmid = 16469769 | doi = 10.1210/me.2005-0426 | doi-access = free }}
- {{cite journal | vauthors = Zhan X, Desiderio DM | title = Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry | journal = Anal. Biochem. | volume = 354 | issue = 2 | pages = 279–89 | year = 2006 | pmid = 16777052 | doi = 10.1016/j.ab.2006.05.024 }}
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