ARMCX5
{{Short description|Protein in Homo sapiens}}
ARMCX5 is an armadillo repeat–containing protein that is encoded by the X-linked ARMCX5 gene. It is conserved only in Eutheria,{{cite web|title=BLAT|url=http://genome.ucsc.edu/cgi-bin/hgBlat|publisher=UCSC Genome Bioinformatics}} a specific group of placental mammals, but no further back in evolutionary time. ARMCX5 contains 3 ARM-like repeats, DUF364, and ARM-type fold.{{cite web|title=ARMCX5|url=https://www.genecards.org/index.php?path=/Search/keyword/armcx5|publisher=Gene cards}}
Features
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| scope="col" style="background:#efefef;" | Accession Number
! scope="col" style="background:#efefef;" | NC_0002.10 |
|---|
| Aliases
|FLJ12969, FLJ13382, and RP4-769N13.3 |
| Chromosomal location
|Xq22.1-q22.3 |
| Gene size
|4991 base pairs |
| mRNA size
|2924 base pairs |
| Protein size
|588 amino acids |
Splice Variants
ARMCX5 has 6 splice variants.
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| scope="col" style="background:#efefef;" | Splice isoform/transcript variant
! scope="col" style="background:#efefef;" | mRNA sequence length ! scope="col" style="background:#efefef;" | Accession number |
|---|
| 1
|2924 |NM_001168479.1 |
| 2
|2695 |NM_022838.3 |
| 3
|2808 |NM_001168478.1 |
| 4
|2918 |NM_001168480.1 |
| 5
|2805 |NM_001168485.1 |
| 6
|2707 |NM_001168482.1 |
ORTHOLOGS
ARMCX5 has ten orthologs.
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| scope="col" style="background:#efefef;" | Ortholog genus name
! scope="col" style="background:#efefef;" | Common name ! scope="col" style="background:#efefef;" | Accession number ! scope="col" style="background:#efefef;" | Sequence length ! scope="col" style="background:#efefef;" | Sequence identity ! scope="col" style="background:#efefef;" | Sequence similarity |
|---|
| Pongo abelli
|Orangatuan |XP_002831961.1 |547 |97.1% |99% |
| Macaca mulata
|Rhesus monkey |EHH30927.1 |558 |95.3% |97% |
| Macaca fascicularis
|Crab eating macaque |EHH61076.1 |558 |95% |97% |
| Callithrix Jacchus
|Common marmoset |XP_002763850.1 |568 |89.4% |93% |
| Equus caballus
|Horse |NC009175.2 |609 |80% |85% |
| Canis lupus familiaris
|dog |XP_538116.2 |608 |79% |85% |
| Sus scrofa
|Common pig |XP_003135327.2 |732 |78% |85% |
| Oryctolagus cuniculus
|Common rabbit |XP_00272091.1 |547 |76.8% |85% |
| Rattus norvegicus
|Common rat |XP_001499348.2 |567 |61.1% |76% |
| Mus musculus
|Mouse |NP_001009575.2 |606 |57% |71% |
Paralogs
Function
Proteins containing this ARMCX5 domain interact with numerous other proteins. Through these interactions, they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation f circadian rhythm and lysosomal sorting of G-protein coupled receptors.
Because DUF364 contains a PLP-dependent transferase-like fold, the genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis.{{cite web|title=NCBI-protein|url=https://www.ncbi.nlm.nih.gov/protein}}
Expression
ARMCX5 is a highly ubiquitously expressed gene that has shown expression in many tissues.
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| scope="col" style="background:#efefef;" | Body Site
! scope="col" style="background:#efefef;" | Transcripts per million ! scope="col" style="background:#efefef;" | Gene EST/Total EST in pool |
|---|
| Brain
|25 |28/1092524 |
| Bone marrow
|82 |4/48711 |
| Mouth
|60 |4/66139 |
| Vascular
|58 |3/51637 |
| Spleen
|56 |3/53365 |
| Mammary gland
|52 |8/151228 |
| Esophagus
|49 |1/20152 |
| Larynx
|42 |1/23489 |
| Trachea
|38 |2/51769 |
| Muscle
|37 |4/106323 |
| Testes
|33 |11/327305 |