ARNT2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.{{cite journal | vauthors = Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC | title = Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis | journal = Genomics | volume = 72 | issue = 1 | pages = 88–98 |date=Mar 2001 | pmid = 11247670 | doi = 10.1006/geno.2000.6466 }}{{cite web | title = Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9915}}
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
References
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External links
- {{UCSC gene info|ARNT2}}
Further reading
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- {{cite journal | vauthors=Nagase T, Ishikawa K, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Moffett P, Pelletier J |title=Different transcriptional properties of mSim-1 and mSim-2. |journal=FEBS Lett. |volume=466 |issue= 1 |pages= 80–6 |year= 2000 |pmid= 10648817 |doi=10.1016/S0014-5793(99)01750-0 |s2cid=30972686 }}
- {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
- {{cite journal | vauthors=Barrow LL, Wines ME, Romitti PA |title=Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. |journal=Teratology |volume=66 |issue= 2 |pages= 85–90 |year= 2003 |pmid= 12210012 |doi= 10.1002/tera.10062 |display-authors=etal}}
- {{cite journal | vauthors=Stolze I, Berchner-Pfannschmidt U, Freitag P |title=Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. |journal=Blood |volume=100 |issue= 7 |pages= 2623–8 |year= 2002 |pmid= 12239177 |doi= 10.1182/blood-2001-12-0169 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ooe N, Saito K, Mikami N |title=Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 608–16 |year= 2004 |pmid= 14701734 |doi=10.1128/MCB.24.2.608-616.2004 | pmc=343817 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
- {{cite journal | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
- {{cite journal | vauthors=Friedman ER, Fan CM |title=Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription. |journal=Biochem. Biophys. Res. Commun. |volume=363 |issue= 1 |pages= 113–8 |year= 2007 |pmid= 17826745 |doi= 10.1016/j.bbrc.2007.08.108 | pmc=2083645 }}
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