ARPC2

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.

ARPC2 has been shown to interact with Cortactin.{{cite journal | vauthors = Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT | title = Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex | journal = J. Cell Biol. | volume = 151 | issue = 1 | pages = 29–40 | date = October 2000 | pmid = 11018051 | pmc = 2189811 | doi = 10.1083/jcb.151.1.29 }}

{{reflist}}

• {{UCSC gene info|ARPC2}}

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• {{cite journal | vauthors = Couch FJ, Rommens JM, Neuhausen SL, Bélanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J | title = Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13 | journal = Genomics | volume = 36 | issue = 1 | pages = 86–99 | year = 1996 | pmid = 8812419 | doi = 10.1006/geno.1996.0428 | doi-access = free }}
• {{cite journal | vauthors = Welch MD, Iwamatsu A, Mitchison TJ | title = Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes | journal = Nature | volume = 385 | issue = 6613 | pages = 265–9 | year = 1997 | pmid = 9000076 | doi = 10.1038/385265a0 | bibcode = 1997Natur.385..265W | s2cid = 4358529 }}
• {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | year = 1999 | pmid = 10235267 | doi = 10.1038/19789 | bibcode = 1999Natur.398..828N | s2cid = 23646963 }}
• {{cite journal | vauthors = Zhao X, Yang Z, Qian M, Zhu X | title = Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub | journal = Biochem. Biophys. Res. Commun. | volume = 280 | issue = 2 | pages = 513–7 | year = 2001 | pmid = 11162547 | doi = 10.1006/bbrc.2000.4151 }}
• {{cite journal | vauthors = Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD | title = Crystal structure of Arp2/3 complex | journal = Science | volume = 294 | issue = 5547 | pages = 1679–84 | year = 2001 | pmid = 11721045 | doi = 10.1126/science.1066333 | bibcode = 2001Sci...294.1679R | s2cid = 18088124 }}
• {{cite journal | vauthors = Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD | title = Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity | journal = Mol. Cell | volume = 8 | issue = 5 | pages = 1041–52 | year = 2001 | pmid = 11741539 | doi = 10.1016/S1097-2765(01)00393-8 | doi-access = free }}
• {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
• {{cite journal | vauthors = Kaneda A, Kaminishi M, Sugimura T, Ushijima T | title = Decreased expression of the seven ARP2/3 complex genes in human gastric cancers | journal = Cancer Lett. | volume = 212 | issue = 2 | pages = 203–10 | year = 2004 | pmid = 15279900 | doi = 10.1016/j.canlet.2004.03.020 }}
• {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
• {{cite journal | vauthors = Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P | title = Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics | journal = Nat. Cell Biol. | volume = 7 | issue = 4 | pages = 353–64 | year = 2005 | pmid = 15793564 | doi = 10.1038/ncb1244 | s2cid = 37000096 }}
• {{cite journal | vauthors = Cai L, Holoweckyj N, Schaller MD, Bear JE | title = Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility | journal = J. Biol. Chem. | volume = 280 | issue = 36 | pages = 31913–23 | year = 2005 | pmid = 16027158 | doi = 10.1074/jbc.M504146200 | doi-access = free }}
• {{cite journal | vauthors = Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE | title = Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge | journal = Cell | volume = 128 | issue = 5 | pages = 915–29 | year = 2007 | pmid = 17350576 | pmc = 2630706 | doi = 10.1016/j.cell.2007.01.031 }}
• {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

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• {{UCSC genome browser|ARPC2}}
• {{UCSC gene details|ARPC2}}

{{PDB Gallery|geneid=10109}}

{{gene-2-stub}}