ARPC3

{{Infobox protein family

| Symbol = P21-Arc

| Name = ARP2/3 complex ARPC3 (21 kDa) subunit

| image = PDB 1u2v EBI.jpg

| width =

| caption = crystal structure of arp2/3 complex with bound adp and calcium

| Pfam = PF04062

| Pfam_clan =

| InterPro = IPR007204

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.{{cite journal | vauthors = Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ | title = The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly | journal = J Cell Biol | volume = 138 | issue = 2 | pages = 375–84 |date=Aug 1997 | pmid = 9230079 | pmc = 2138188 | doi =10.1083/jcb.138.2.375 }}{{cite journal | vauthors = Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW | title = Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins | journal = Biochem J | volume = 328 | issue = 1| pages = 105–12 |date=Jan 1998 | pmid = 9359840 | pmc = 1218893 | doi = 10.1042/bj3280105}}{{cite web | title = Entrez Gene: ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10094| accessdate = }}

This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.

References

{{cite journal | vauthors=Welch MD, Iwamatsu A, Mitchison TJ |title=Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. |journal=Nature |volume=385 |issue= 6613 |pages= 265–9 |year= 1997 |pmid= 9000076 |doi= 10.1038/385265a0 |bibcode=1997Natur.385..265W |s2cid=4358529 }}
{{cite journal | vauthors=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590 |s2cid=30437883 }}
{{cite journal | vauthors=Zhao X, Yang Z, Qian M, Zhu X |title=Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 513–7 |year= 2001 |pmid= 11162547 |doi= 10.1006/bbrc.2000.4151 }}
{{cite journal | vauthors=Robinson RC, Turbedsky K, Kaiser DA |title=Crystal structure of Arp2/3 complex. |journal=Science |volume=294 |issue= 5547 |pages= 1679–84 |year= 2001 |pmid= 11721045 |doi= 10.1126/science.1066333 |bibcode=2001Sci...294.1679R |s2cid=18088124 |display-authors=etal}}
{{cite journal | vauthors=Gournier H, Goley ED, Niederstrasser H |title=Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1041–52 |year= 2002 |pmid= 11741539 |doi=10.1016/S1097-2765(01)00393-8 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |display-authors=etal|doi-access=free |bibcode=2002CBio...12....1A }}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 |display-authors=etal}}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
{{cite journal | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 |display-authors=etal}}
{{cite journal | vauthors=Dubois T, Paléotti O, Mironov AA |title=Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. |journal=Nat. Cell Biol. |volume=7 |issue= 4 |pages= 353–64 |year= 2005 |pmid= 15793564 |doi= 10.1038/ncb1244 |s2cid=37000096 |display-authors=etal}}
{{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|hdl=11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access=free }}
{{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}

External links

{{UCSC genome browser|ARPC3}}
{{UCSC gene details|ARPC3}}

ARPC3

References

Further reading

External links