ARPC4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene.{{cite journal | vauthors = Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ | title = The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly | journal = J. Cell Biol. | volume = 138 | issue = 2 | pages = 375–84 | date = August 1997 | pmid = 9230079 | pmc = 2138188 | doi = 10.1083/jcb.138.2.375 }}{{cite journal | vauthors = Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW | title = Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins | journal = Biochem. J. | volume = 328 ( Pt 1) | issue = 1 | pages = 105–12 | year = 1997 | pmid = 9359840 | pmc = 1218893 | doi = 10.1042/bj3280105 }}{{cite web | title = Entrez Gene: ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10093}}
Function
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p20 subunit, has yet to be determined. Three transcript variants encoding two distinct isoforms have been found for this gene.
Interactions
ARPC4 has been shown to interact with ARPC5.{{cite journal | vauthors = Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM | title = Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5 | journal = Cell Motil. Cytoskeleton | volume = 54 | issue = 1 | pages = 81–90 | year = 2003 | pmid = 12451597 | doi = 10.1002/cm.10087 }}{{cite journal | vauthors = Zhao X, Yang Z, Qian M, Zhu X | title = Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub | journal = Biochem. Biophys. Res. Commun. | volume = 280 | issue = 2 | pages = 513–7 | year = 2001 | pmid = 11162547 | doi = 10.1006/bbrc.2000.4151 }}
References
{{Reflist}}
Further reading
{{Refbegin | 2}}
- {{cite journal | vauthors = Welch MD, Iwamatsu A, Mitchison TJ | title = Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes | journal = Nature | volume = 385 | issue = 6613 | pages = 265–9 | year = 1997 | pmid = 9000076 | doi = 10.1038/385265a0 | bibcode = 1997Natur.385..265W | s2cid = 4358529 }}
- {{cite journal | vauthors = Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD | s2cid = 18088124 | title = Crystal structure of Arp2/3 complex | journal = Science | volume = 294 | issue = 5547 | pages = 1679–84 | year = 2001 | pmid = 11721045 | doi = 10.1126/science.1066333 | bibcode = 2001Sci...294.1679R }}
- {{cite journal | vauthors = Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD | title = Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity | journal = Mol. Cell | volume = 8 | issue = 5 | pages = 1041–52 | year = 2001 | pmid = 11741539 | doi = 10.1016/S1097-2765(01)00393-8 | doi-access = free }}
- {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
- {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
- {{cite journal | vauthors = Rosentreter A, Hofmann A, Xavier CP, Stumpf M, Noegel AA, Clemen CS | title = Coronin 3 involvement in F-actin-dependent processes at the cell cortex | journal = Exp. Cell Res. | volume = 313 | issue = 5 | pages = 878–95 | year = 2007 | pmid = 17274980 | doi = 10.1016/j.yexcr.2006.12.015 | hdl = 10072/14982 | hdl-access = free }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
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