ASAH2B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.{{cite journal | vauthors = Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS | title = A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease | journal = Neurogenetics | volume = 8 | issue = 2 | pages = 111–20 |date=April 2007 | pmid = 17334805 | doi = 10.1007/s10048-007-0081-5 | s2cid = 20156514 }}{{cite journal | vauthors = Deloukas P, Earthrowl ME, Grafham DV | title = The DNA sequence and comparative analysis of human chromosome 10 | journal = Nature | volume = 429 | issue = 6990 | pages = 375–81 |date=May 2004 | pmid = 15164054 | doi = 10.1038/nature02462 | bibcode = 2004Natur.429..375D |display-authors=etal| doi-access = free }}
Clinical significance
ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.
References
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External links
- {{UCSC gene info|ASAH2B}}
Further reading
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- {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2004 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 |display-authors=etal}}
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{{Glycolipid/sphingolipid metabolism enzymes}}
{{gene-10-stub}}