ASIC1

This gene encodes a member of the ASIC/ENaC superfamily of proteins.{{cite journal | vauthors = Hanukoglu I, Hanukoglu A | title = Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. | journal = Gene | volume = 579 | issue = 2 | pages = 95–132 | date = Jan 2016 | pmid = 26772908 | doi = 10.1016/j.gene.2015.12.061 | pmc = 4756657}} The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).

The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.

ASIC1 has been shown to interact with PICK1.{{cite journal | vauthors = Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ | title = cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 4 | pages = 2029–34 | date = February 2003 | pmid = 12578970 | pmc = 149953 | doi = 10.1073/pnas.252782799 | bibcode = 2003PNAS..100.2029L | doi-access = free }}{{cite journal | vauthors = Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ | title = Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel) | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 443–50 | date = February 2002 | pmid = 11802773 | pmc = 1222326 | doi = 10.1042/0264-6021:3610443 }}

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• {{cite journal | vauthors = Corey DP, García-Añoveros J | title = Mechanosensation and the DEG/ENaC ion channels | journal = Science | volume = 273 | issue = 5273 | pages = 323–4 | year = 1996 | pmid = 8685718 | doi = 10.1126/science.273.5273.323 | bibcode = 1996Sci...273..323C | s2cid = 9015840 }}
• {{cite journal | vauthors = Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M | title = A proton-gated cation channel involved in acid-sensing | journal = Nature | volume = 386 | issue = 6621 | pages = 173–7 | year = 1997 | pmid = 9062189 | doi = 10.1038/386173a0 | bibcode = 1997Natur.386..173W | s2cid = 4361943 }}
• {{cite journal | vauthors = Bubien JK, Keeton DA, Fuller CM, Gillespie GY, Reddy AT, Mapstone TB, Benos DJ | title = Malignant human gliomas express an amiloride-sensitive Na+ conductance | journal = Am. J. Physiol. | volume = 276 | issue = 6 Pt 1 | pages = C1405–10 | year = 1999 | pmid = 10362604 | doi = 10.1152/ajpcell.1999.276.6.C1405}}
• {{cite journal | vauthors = Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ | title = Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels | journal = Neuron | volume = 26 | issue = 1 | pages = 133–41 | year = 2000 | pmid = 10798398 | doi = 10.1016/S0896-6273(00)81144-7 | s2cid = 14077330 | doi-access = free }}
• {{cite journal | vauthors = Bässler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S | title = Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 33782–7 | year = 2001 | pmid = 11448963 | doi = 10.1074/jbc.M104030200 | doi-access = free }}
• {{cite journal | vauthors = Gunthorpe MJ, Smith GD, Davis JB, Randall AD | title = Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells | journal = Pflügers Arch. | volume = 442 | issue = 5 | pages = 668–74 | year = 2001 | pmid = 11512022 | doi = 10.1007/s004240100584 | s2cid = 19059975 }}
• {{cite journal | vauthors = Duggan A, Garcia-Anoveros J, Corey DP | title = The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5203–8 | year = 2002 | pmid = 11739374 | doi = 10.1074/jbc.M104748200 | doi-access = free }}
• {{cite journal | vauthors = Ji HL, Jovov B, Fu J, Bishop LR, Mebane HC, Fuller CM, Stanton BA, Benos DJ | title = Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8395–405 | year = 2002 | pmid = 11748227 | doi = 10.1074/jbc.M109465200 | doi-access = free }}
• {{cite journal | vauthors = Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ | title = Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel) | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 443–50 | year = 2002 | pmid = 11802773 | pmc = 1222326 | doi = 10.1042/0264-6021:3610443 }}
• {{cite journal | vauthors = Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ | title = The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory | journal = Neuron | volume = 34 | issue = 3 | pages = 463–77 | year = 2002 | pmid = 11988176 | doi = 10.1016/S0896-6273(02)00661-X | s2cid = 2619519 | doi-access = free }}
• {{cite journal | vauthors = Berdiev BK, Xia J, Jovov B, Markert JM, Mapstone TB, Gillespie GY, Fuller CM, Bubien JK, Benos DJ | title = Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function | journal = J. Biol. Chem. | volume = 277 | issue = 48 | pages = 45734–40 | year = 2003 | pmid = 12244121 | doi = 10.1074/jbc.M208995200 | doi-access = free }}
• {{cite journal | vauthors = Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S | title = Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors | journal = J. Clin. Invest. | volume = 110 | issue = 8 | pages = 1185–90 | year = 2002 | pmid = 12393854 | pmc = 150796 | doi = 10.1172/JCI15709 }}
• {{cite journal | vauthors = Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ | title = cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 4 | pages = 2029–34 | year = 2003 | pmid = 12578970 | pmc = 149953 | doi = 10.1073/pnas.252782799 | bibcode = 2003PNAS..100.2029L | doi-access = free }}
• {{cite journal | vauthors = Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ | title = Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 10 | pages = 3621–6 | year = 2004 | pmid = 14988500 | pmc = 373512 | doi = 10.1073/pnas.0308753101 | bibcode = 2004PNAS..101.3621W | doi-access = free }}
• {{cite journal | vauthors = Poirot O, Vukicevic M, Boesch A, Kellenberger S | title = Selective regulation of acid-sensing ion channel 1 by serine proteases | journal = J. Biol. Chem. | volume = 279 | issue = 37 | pages = 38448–57 | year = 2004 | pmid = 15247234 | doi = 10.1074/jbc.M407381200 | doi-access = free }}
• {{cite journal | vauthors = Price MP, Thompson RJ, Eshcol JO, Wemmie JA, Benson CJ | title = Stomatin modulates gating of acid-sensing ion channels | journal = J. Biol. Chem. | volume = 279 | issue = 51 | pages = 53886–91 | year = 2005 | pmid = 15471860 | doi = 10.1074/jbc.M407708200 | doi-access = free }}

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• {{UCSC gene info|ASIC1}}

{{Ion channels|g2}}

Category:Sodium channels

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