ATP12A

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.

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• {{UCSC gene info|ATP12A}}

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• {{cite journal | vauthors=Modyanov NN, Petrukhin KE, Sverdlov VE |title=The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. |journal=FEBS Lett. |volume=278 |issue= 1 |pages= 91–4 |year= 1991 |pmid= 1847115 |doi=10.1016/0014-5793(91)80091-G |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Yang-Feng TL, Schneider JW, Lindgren V |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=10.1016/0888-7543(88)90094-8 |display-authors=etal}}
• {{cite journal | vauthors=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=10.1073/pnas.84.12.4039 | pmc=305017 |doi-access=free }}
• {{cite journal | vauthors=Sverdlov ED, Monastyrskaya GS, Broude NE |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=10.1016/0014-5793(87)80677-4 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN |title=Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 144–50 |year= 1994 |pmid= 8045293 |doi=10.1016/0014-5793(94)00655-5 |doi-access=free }}
• {{cite journal | vauthors=Sverdlov VE, Kostina MB, Modyanov NN |title=Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase. |journal=Genomics |volume=32 |issue= 3 |pages= 317–27 |year= 1997 |pmid= 8838794 |doi= 10.1006/geno.1996.0125 }}
• {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
• {{cite journal | vauthors=Pestov NB, Romanova LG, Korneenko TV |title=Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. |journal=FEBS Lett. |volume=440 |issue= 3 |pages= 320–4 |year= 1999 |pmid= 9872395 |doi=10.1016/S0014-5793(98)01483-5 |s2cid=83264565 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Pestov NB, Korneenko TV, Adams G |title=Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 4 |pages= C907–16 |year= 2002 |pmid= 11880279 |doi= 10.1152/ajpcell.00258.2001 |s2cid=19898937 |display-authors=etal}}
• {{cite journal | vauthors=Reinhardt J, Kosch M, Lerner M |title=Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F335–43 |year= 2002 |pmid= 12110518 |doi= 10.1152/ajprenal.00226.2001 |s2cid=7158036 |display-authors=etal}}
• {{cite journal | vauthors=Takahashi Y, Sakai H, Kuragari M |title=Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. |journal=Jpn. J. Physiol. |volume=52 |issue= 3 |pages= 317–21 |year= 2003 |pmid= 12230809 |doi=10.2170/jjphysiol.52.317 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Li J, Codina J, Petroske E |title=The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function. |journal=Kidney Int. |volume=65 |issue= 4 |pages= 1301–10 |year= 2004 |pmid= 15086469 |doi= 10.1111/j.1523-1755.2004.00507.x |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Johansson M, Jansson T, Pestov NB, Powell TL |title=Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. |journal=Placenta |volume=25 |issue= 6 |pages= 505–11 |year= 2004 |pmid= 15135233 |doi= 10.1016/j.placenta.2003.11.008 }}
• {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}

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{{gene-13-stub}}{{Ion pumps}}