ATP1B3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.{{cite journal | vauthors = Malik N, Canfield VA, Beckers MC, Gros P, Levenson R | title = Identification of the mammalian Na,K-ATPase 3 subunit | journal = J Biol Chem | volume = 271 | issue = 37 | pages = 22754–8 |date=Nov 1996 | pmid = 8798450 | doi =10.1074/jbc.271.37.22754 | doi-access = free }}{{cite journal | vauthors = Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R | title = Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene | journal = Mamm Genome | volume = 9 | issue = 2 | pages = 136–43 |date=Mar 1998 | pmid = 9457675 | doi =10.1007/s003359900704 | s2cid = 31228553 }} ATP1B3 has also been designated as CD298 (cluster of differentiation 298).
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.{{cite web | title = Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=483}}
References
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Further reading
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- {{cite journal | vauthors=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=10.1016/S0079-6603(08)60708-4 | series=Progress in Nucleic Acid Research and Molecular Biology | isbn=978-0-12-540038-1 }}
- {{cite journal | author=Jørgensen PL |title=Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase |journal=Biochim. Biophys. Acta |volume=694 |issue= 1 |pages= 27–68 |year= 1982 |pmid= 6289898 |doi= 10.1016/0304-4157(82)90013-2}}
- {{cite journal | vauthors=Chiampanichayakul S, Szekeres A, Khunkaewla P |title=Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation |journal=Int. Immunol. |volume=14 |issue= 12 |pages= 1407–14 |year= 2003 |pmid= 12456588 |doi=10.1093/intimm/dxf112 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 |s2cid=581283 }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Chi A, Valencia JC, Hu ZZ |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j |display-authors=etal}}
- {{cite journal | vauthors=Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W |title=Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells |journal=Tissue Antigens |volume=68 |issue= 6 |pages= 509–17 |year= 2007 |pmid= 17176442 |doi= 10.1111/j.1399-0039.2006.00726.x }}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
- {{cite journal | vauthors=Aughey RJ, Murphy KT, Clark SA |title=Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes |journal=J. Appl. Physiol. |volume=103 |issue= 1 |pages= 39–47 |year= 2007 |pmid= 17446412 |doi= 10.1152/japplphysiol.00236.2006 |s2cid=7370462 |display-authors=etal}}
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External links
- {{MeshName|ATP1B3+protein,+human}}
- {{UCSC gene info|ATP1B3}}
{{NLM content}}
{{Clusters of differentiation}}
{{ATPases}}
Category:Clusters of differentiation
{{membrane-protein-stub}}