ATP5PF

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F_O, which comprises the proton channel. The F₁ complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F_O seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the F_O complex, required for F₁ and F_O interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

The F6 subunit is part of the peripheral stalk that links the F₁ and F_O complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterial F-ATPases. In mitochondria, the peripheral stalk is composed of one copy each of subunits OSCP (oligomycin sensitivity conferral protein), F6, b and d.{{cite journal | vauthors = Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D | title = Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit | journal = Journal of Molecular Biology | volume = 351 | issue = 4 | pages = 824–38 | date = Aug 2005 | pmid = 16045926 | doi = 10.1016/j.jmb.2005.06.012 }} There is no homologue of subunit F6 in bacterial or chloroplast F-ATPase, whose peripheral stalks are composed of one copy of the delta subunit (homologous to OSCP), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosynthetic bacteria.

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• {{UCSC gene info|ATP5PF}}

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• {{cite journal | vauthors = Yan WL, Lerner TJ, Haines JL, Gusella JF | title = Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3) | journal = Genomics | volume = 24 | issue = 2 | pages = 375–7 | date = Nov 1994 | pmid = 7698763 | doi = 10.1006/geno.1994.1631 }}
• {{cite journal | vauthors = Elston T, Wang H, Oster G | title = Energy transduction in ATP synthase | journal = Nature | volume = 391 | issue = 6666 | pages = 510–3 | date = Jan 1998 | pmid = 9461222 | doi = 10.1038/35185 | bibcode = 1998Natur.391..510E | s2cid = 4406161 }}
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{{InterPro content|IPR008387}}

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