ATP5S
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.{{cite journal | vauthors = Belogrudov GI, Hatefi Y | title = Factor B and the mitochondrial ATP synthase complex | journal = J Biol Chem | volume = 277 | issue = 8 | pages = 6097–103 |date=Feb 2002 | pmid = 11744738 | doi = 10.1074/jbc.M111256200 | doi-access = free }}{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal Biochem | volume = 236 | issue = 1 | pages = 107–13 |date=Jun 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}{{cite web | title = Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27109}}
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
{{reflist}}
External links
- {{UCSC gene info|ATP5S}}
- [http://gen-script.com/ATP5S-gene-atp-synthase-h-transporting-mitochondrial-fo-complex-subunit-s-factor-b ATP5S: ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)]
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Kinosita K, Yasuda R, Noji H |title=F1-ATPase: a highly efficient rotary ATP machine |journal=Essays Biochem. |volume=35 |pages= 3–18 |year= 2003 |pmid= 12471886 |doi= 10.1042/bse0350003}}
- {{cite journal | vauthors=Oster G, Wang H |title=Rotary protein motors |journal=Trends Cell Biol. |volume=13 |issue= 3 |pages= 114–21 |year= 2003 |pmid= 12628343 |doi=10.1016/S0962-8924(03)00004-7 }}
- {{cite journal | vauthors=Leyva JA, Bianchet MA, Amzel LM |title=Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review) |journal=Mol. Membr. Biol. |volume=20 |issue= 1 |pages= 27–33 |year= 2003 |pmid= 12745923 |doi=10.1080/0968768031000066532 |s2cid=218895820 |doi-access=free }}
- {{cite journal | vauthors=Sanadi DR, Pringle M, Kantham L |title=Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 5 |pages= 1371–4 |year= 1984 |pmid= 6143319 |doi=10.1073/pnas.81.5.1371 | pmc=344835 |bibcode=1984PNAS...81.1371S |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
- {{cite journal | vauthors=Elston T, Wang H, Oster G |title=Energy transduction in ATP synthase |journal=Nature |volume=391 |issue= 6666 |pages= 510–3 |year= 1998 |pmid= 9461222 |doi= 10.1038/35185 |bibcode=1998Natur.391..510E |s2cid=4406161 }}
- {{cite journal | vauthors=Wang H, Oster G |title=Energy transduction in the F1 motor of ATP synthase |journal=Nature |volume=396 |issue= 6708 |pages= 279–82 |year= 1998 |pmid= 9834036 |doi= 10.1038/24409 |bibcode=1998Natur.396..279W |s2cid=4424498 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | author=Cross RL |title=Molecular motors: turning the ATP motor |journal=Nature |volume=427 |issue= 6973 |pages= 407–8 |year= 2004 |pmid= 14749816 |doi= 10.1038/427407b |bibcode=2004Natur.427..407C |doi-access= free }}
- {{cite journal | vauthors=Ma J, Dempsey AA, Stamatiou D |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 |display-authors=etal}}
{{refend}}
{{gene-14-stub}}