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AZI2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.{{cite journal | vauthors = Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S | title = Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus | journal = Gene | volume = 240 | issue = 2 | pages = 289–95 |date=Jan 2000 | pmid = 10580148 | doi =10.1016/S0378-1119(99)00450-3 }}{{cite web | title = Entrez Gene: AZI2 5-azacytidine induced 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64343}}

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM]

References

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External links

  • {{UCSC gene info|AZI2}}

Further reading

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  • {{cite journal | author=Funami K |title=Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA |journal=J. Immunol. |volume=179 |issue= 10 |pages= 6867–72 |year= 2007 |pmid= 17982077 |doi= 10.4049/jimmunol.179.10.6867| author2=Sasai M | author3=Ohba Y | last4=Oshiumi | first4=H | last5=Seya | first5=T | last6=Matsumoto | first6=M | doi-access=free}}
  • {{cite journal | author=Sasai M |title=NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction |journal=J. Immunol. |volume=177 |issue= 12 |pages= 8676–83 |year= 2007 |pmid= 17142768 |doi= 10.4049/jimmunol.177.12.8676| author2=Shingai M | author3=Funami K | last4=Yoneyama | first4=M | last5=Fujita | first5=T | last6=Matsumoto | first6=M | last7=Seya | first7=T | doi-access=free }}
  • {{cite journal | author=Sasai M |title=Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation |journal=J. Immunol. |volume=174 |issue= 1 |pages= 27–30 |year= 2005 |pmid= 15611223 |doi= 10.4049/jimmunol.174.1.27| author2=Oshiumi H | author3=Matsumoto M | last4=Inoue | first4=N | last5=Fujita | first5=F | last6=Nakanishi | first6=M | last7=Seya | first7=T | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 | author2=Bauch A | author3=Ruffner H | last4=Angrand | first4=Pierre-Olivier | last5=Bergamini | first5=Giovanna | last6=Croughton | first6=Karen | last7=Cruciat | first7=Cristina | last8=Eberhard | first8=Dirk | last9=Gagneur | first9=Julien |s2cid=11683986 }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Fujita F |title=Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7780–93 |year= 2003 |pmid= 14560022 |doi=10.1128/MCB.23.21.7780-7793.2003 | pmc=207563 | author2=Taniguchi Y | author3=Kato T | last4=Narita | first4=Y. | last5=Furuya | first5=A. | last6=Ogawa | first6=T. | last7=Sakurai | first7=H. | last8=Joh | first8=T. | last9=Itoh | first9=M. }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}

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