Abigail Doyle

{{Infobox scientist

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| name = Abigail G. Doyle

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| birth_date = {{Birth date and age|year=1980|month=04|day=30}}

| birth_place = Princeton, New Jersey, U.S.

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| fields = Organic Chemistry, Organometallic chemistry, Catalysis

| workplaces = University of California, Los Angeles

Princeton University

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| alma_mater = Harvard University (BA, MA, PhD)

| thesis_title = Engaging alkyl halides and oxocarbenium ions in asymmetric catalysis

| thesis_url = https://www.proquest.com/pqdtglobal/docview/304599046/C56030AD241E4BBEPQ

| thesis_year = 2008

| doctoral_advisor = Eric N. Jacobsen

| academic_advisors = Justin DuBois

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| notable_students = Julia Kalow

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| awards = Arthur C. Cope Scholar Award, Elias J. Corey Award

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| father = Michael W. Doyle

| mother = Amy Gutmann

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| website = {{URL|https://doyle.chem.ucla.edu/}}

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Abigail Gutmann Doyle is a professor of chemistry at the University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry.{{Cite web|last=Jennings|first=Penny|date=Jun 30, 2021|title=Welcome Professor Abigail Doyle {{!}} UCLA Chemistry and Biochemistry|url=https://www.chemistry.ucla.edu/news/welcome-professor-abigail-doyle|access-date=2021-07-01|website=www.chemistry.ucla.edu}} Her research focuses on the development of new chemical transformations in organic chemistry.

Early life and education

Doyle was born in Princeton, NJ in 1980 to Michael W. Doyle and Amy Gutmann, the eighth president of the University of Pennsylvania and later the United States Ambassador to Germany. Doyle studied chemistry as an undergraduate at Harvard University, graduating with A.B. and A.M. degrees summa cum laude in 2002. In 2003, she went to Harvard University and joined the lab of Professor Eric Jacobsen.{{Cite web |title=Acceleration Consortium |url=https://acceleration.utoronto.ca/researcher/abigail-doyle |access-date=2025-01-31 |website=acceleration.utoronto.ca}}

After beginning graduate studies in the lab of Justin DuBois at Stanford University, Doyle completed her Ph.D. under Prof. Eric N. Jacobsen, where she developed enantioselective alkylations with tributyltin enolates catalyzed by a Cr(salen)Cl catalyst.{{Cite journal|last1=Doyle|first1=Abigail G.|last2=Jacobsen|first2=Eric N.|date=2005-01-01|title=Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All-Carbon Quaternary Centers|url=https://doi.org/10.1021/ja043601p|journal=Journal of the American Chemical Society|volume=127|issue=1|pages=62–63|doi=10.1021/ja043601p|pmid=15631449|bibcode=2005JAChS.127...62D |issn=0002-7863|url-access=subscription}}{{Cite journal|last1=Doyle|first1=Abigail G.|last2=Jacobsen|first2=Eric N.|date=2007|title=Enantioselective Alkylation of Acyclic α,α-Disubstituted Tributyltin Enolates Catalyzed by a Cr(salen) Complex|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200604901|journal=Angewandte Chemie International Edition|volume=46|issue=20|pages=3701–3705|doi=10.1002/anie.200604901|pmid=17407117|issn=1521-3773|url-access=subscription}} She also worked on the development of an enantioselective addition of nucleophiles to oxocarbenium ions.{{Cite journal|last1=Reisman|first1=Sarah E.|last2=Doyle|first2=Abigail G.|last3=Jacobsen|first3=Eric N.|date=2008-06-01|title=Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions|url=https://doi.org/10.1021/ja801514m|journal=Journal of the American Chemical Society|volume=130|issue=23|pages=7198–7199|doi=10.1021/ja801514m|issn=0002-7863|pmc=2574628|pmid=18479086|bibcode=2008JAChS.130.7198R }}

Career

;Independent career

In July 2008, Doyle was appointed as an assistant professor of chemistry at Princeton University. She was promoted to the rank of associate professor with tenure in 2013, and to full Professor with an endowed chair, the A. Barton Hepburn Professor of Chemistry, in 2017.[http://chemlabs.princeton.edu/doyle/people/about-abby/ The Doyle Group] {{Webarchive|url=https://web.archive.org/web/20171114155615/http://chemlabs.princeton.edu/doyle/people/about-abby/|date=2017-11-14}}, Princeton University In 2021, she moved to the University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry. She studies catalysis and physical organic chemistry. {{Cite web |title=Doyle, Abigail – UCLA |url=https://www.chemistry.ucla.edu/directory/doyle-abigail/ |archive-url=http://web.archive.org/web/20241111125823/https://www.chemistry.ucla.edu/directory/doyle-abigail/ |archive-date=2024-11-11 |access-date=2025-02-10 |website=www.chemistry.ucla.edu |language=en-US}}

In 2021 She was selected as one of the Cell Press 50 scientists.

Research

A longstanding research interest of the Doyle group is the development of nickel-catalyzed C–C bond forming reactions that utilize unconventional cross-coupling electrophiles, such as epoxides, aziridines, imminium ions, and oxocarbenium ions. The group has developed and mechanistically interrogated new ligands and pre-catalysts for nickel, which have helped to enable these transformations. In collaboration with David MacMillan's group, the Doyle lab identified a new cross-coupling paradigm which allows the combination of photoredox and nickel catalysis.{{Cite journal|last1=Zuo|first1=Zhiwei|last2=Ahneman|first2=Derek T.|last3=Chu|first3=Lingling|last4=Terrett|first4=Jack A.|last5=Doyle|first5=Abigail G.|last6=MacMillan|first6=David W. C.|date=2014-07-25|title=Merging photoredox with nickel catalysis: Coupling of α-carboxyl sp3-carbons with aryl halides|journal=Science|language=en|volume=345|issue=6195|pages=437–440|doi=10.1126/science.1255525|issn=0036-8075|pmc=4296524|pmid=24903563|bibcode=2014Sci...345..437Z}} The Doyle lab has subsequently applied Nickel/photoredox catalysis to methodologies involving both unconventional and traditional cross-coupling electrophiles.

The group has also been involved in the development of nucleophilic fluorination chemistry allowing the creation of pharmaceutically relevant molecules with sp³-C-F and sp²-C-F bonds. These methods have employed both transition metal and photoredox catalysis, and the group has developed new reagents for mild and selective deoxyfluorination reactions.

Recently, the Doyle group has worked in the area of data science-driven analysis of chemical reactions, including the implementation of machine learning algorithms to model and predict reaction outcome in organic chemistry.{{Cite journal|last1=Ahneman|first1=Derek T.|last2=Estrada|first2=Jesus G. J.|last3=Lin|first3=Shishi|last4=Dreher|first4=Spencer D.|last5=Doyle|first5=Abigail G.|date=2018-02-15|title=Predicting reaction performance in C–N cross-coupling using machine learning|journal=Science|language=en|volume=360|issue=6385|pages=186–190|doi= 10.1126/science.aar5169|pmid=29449509 |bibcode=2018Sci...360..186A |s2cid=206666015 |doi-access=free}}{{Cite journal|last1=Shields|first1=Benjamin J.|last2=Stevens|first2=Jason|last3=Li|first3=Jun|last4=Parasram|first4=Marvin|last5=Damani|first5=Farhan|last6=Martinez Alvarado|first6=Jesus I.|last7=Janey|first7=Jacob M.|last8=Adams|first8=Ryan P.|last9=Doyle|first9=Abigail G.|date=2021-02-03|title=Bayyesian reaction optimization as a tool for chemical synthesis|journal=Nature|language=en|volume=590|issue=7844 |pages=89–96|doi=10.1038/s41586-021-03213-y|pmid= 33536653|bibcode=2021Natur.590...89S |s2cid=231804657 }}{{Cite journal|last1=Żurański|first1=Andrzej M.|last2=Martinez Alvarado|first2=Jesus I.|last3=Shields|first3=Benjamin J.|last4=Doyle|first4=Abigail G.|date=2021-03-31|title=Predicting Reaction Yields via Supervised Learning|journal=Accounts of Chemical Research|language=en|volume=54|issue=8 |pages=1856–1865|doi=10.1021/acs.accounts.0c00770|pmid=33788552 |s2cid=232483029 }}

Awards and honors

Some key awards of Doyle's independent career include the Alfred P. Sloan Foundation Fellowship (Alfred P. Sloan Foundation, 2012),{{Cite web|url=https://sloan.org/past-fellows|title=Past Fellows|website=sloan.org|access-date=2018-09-02|archive-date=2018-03-14|archive-url=https://web.archive.org/web/20180314000756/https://sloan.org/past-fellows|url-status=dead}} Amgen Young Investigator Award (2012), Arthur C. Cope Scholar Award (American Chemical Society, 2014),{{Cite web|url=https://cen.acs.org/articles/92/i11/2014-Arthur-C-Cope-Scholar0.html|title=2014 Arthur C. Cope Scholar Awards: Abigail G. Doyle {{!}} Chemical & Engineering News|last=Ritter|first=Stephen K.|website=cen.acs.org|access-date=2018-09-02}} Bayer Early Excellence in Science Award (2013), Phi Lambda Upsilon National Fresenius Award (Phi Lamba Upsilon, 2014), Presidential Early Career Award for Scientists and Engineers (PECASE, 2014) BMS Unrestricted Grant in Synthetic Organic Chemistry (2016).{{Cite web|title=Abigail Doyle {{!}} Princeton University Department of Chemistry|url=https://chemistry.princeton.edu/faculty/abigail-doyle#honors|access-date=2020-10-27|website=chemistry.princeton.edu}}

She was a finalist for the Blavatnik National Award for Young Scientists in 2022.{{Cite web |last=Blavatnik |date=2024 |title=US National Honorees |url=https://blavatnikawards.org/honorees/national-finalists/ |website=Blavatnik Awards}}

She is currently Senior Editor, Accounts of Chemical Research.{{Cite web|url=https://pubs.acs.org/page/achre4/editors.html|title=Editors|website=pubs.acs.org|language=en|access-date=2018-09-02}}

Doyle has also been awarded the OMCOS Award in 2023.

References

Category:Living people

Category:Harvard College alumni

Category:Princeton University faculty

Category:21st-century American chemists

Category:American people of German-Jewish descent

Category:Jewish American scientists

Category:1980 births

Category:21st-century American Jews

Category:Harvard Graduate School of Arts and Sciences alumni

Category:Recipients of the Presidential Early Career Award for Scientists and Engineers