Acridone alkaloids
File:Acridone Structural Formula V1.svg, parent compound of the acridone alkaloids.]]
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Acridone alkaloids are natural products derived from acridone.{{RömppOnline|Name=Acridone|Datum=21 April 2020 |ID=RD-01-00605}}
Occurrence
Acridone alkaloids are found in bark, wood, leaves and roots of rue plants, especially in roots and suspension cultures of rue.{{citation|surname1=R. Hänsel, O.Sticher|title=Pharmakognosie Phytopharmazie|edition=8|publisher=Springer Medizin Verlag|publication-place=Heidelberg|at=pp. 101,1326|isbn=9783540265085|date=2007|language=German
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Examples
This group is named after the acridone. Further members are acronycin, melicopicine and rutacridone, among others:{{cite web|title=Acridone alkaloid biosynthesis|periodical=|publisher=|url=https://www.genome.jp/kegg/pathway/map/map01058.html|url-status=dead|format=|access-date=22 April 2020|archive-url=https://web.archive.org/web/20200612075938/https://www.genome.jp/kegg/pathway/map/map01058.html|archive-date=12 June 2020|last=|date=|year=|language=en|pages=|quote=}}
Acronycine Structural Formula V1.svg|Acronycin
Melicopicine Structural Formula V1.svg|Melicopicine
Rutacridone Structural Formula V1.svg|Rutacridon
Properties
Many acridone alkaloids are methylated on the nitrogen atom and also have two oxygen functional groups, which can be free, alkylated or incorporated into rings. Acridone alkaloids show a blue-green fluorescence so that they can be detected with UV light. Some alkaloids of this group are effective against malaria pathogens. Furthermore, acronycin inhibits cell division.