Acrospiroma

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| synonym = Hidradenoma

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| caption = Tubular hidradenoma, apocrine

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| specialty = dermatology

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Acrospiromas are a broad class of benign cutaneous adnexal tumors.{{cite journal | vauthors = Miller AC, Adjei S, Temiz LA, Gill P, Siller A, Tyring SK | title = Dermal Duct Tumor: A Diagnostic Dilemma | journal = Dermatopathology | volume = 9 | issue = 1 | pages = 36–47 | date = January 2022 | pmid = 35225875 | pmc = 8883970 | doi = 10.3390/dermatopathology9010007 | url = | doi-access = free }} Cutaneous adnexal tumors are a group of skin tumors consisting of tissues that have differentiated (i.e. matured from stem cells) towards one or more of the four primary adnexal structures found in normal skin: hair follicles, sebaceous sweat glands, apocrine sweat glands, and eccrine sweat glands.{{cite journal | vauthors = Zaballos P, Gómez-Martín I, Martin JM, Bañuls J | title = Dermoscopy of Adnexal Tumors | journal = Dermatologic Clinics | volume = 36 | issue = 4 | pages = 397–412 | date = October 2018 | pmid = 30201149 | doi = 10.1016/j.det.2018.05.007 | s2cid = 52185272 | url = }} Acrospiromas are thought to derive from apocrine or eccrine sweat gland ducts near their acrosyringium, i.e. point where these ducts open to the skin's surface.{{cite journal | vauthors = Bijou W, Laababsi R, Oukessou Y, Rouadi S, Abada R, Roubal M, Mahtar M | title = An unusual presentation of a nodular hidradenoma: A case report and review of the literature | journal = Annals of Medicine and Surgery (2012) | volume = 61 | issue = | pages = 61–63 | date = January 2021 | pmid = 33384876 | pmc = 7772521 | doi = 10.1016/j.amsu.2020.11.050 | url = }}{{cite journal | vauthors = Sawaya JL, Khachemoune A | title = Poroma: a review of eccrine, apocrine, and malignant forms | journal = International Journal of Dermatology | volume = 53 | issue = 9 | pages = 1053–61 | date = September 2014 | pmid = 24697501 | doi = 10.1111/ijd.12448 | url = | doi-access = free }}

The acrospiroma group of tumors consists of: 1) the hidradenomas, including their eccrine acrospiroma, clear cell hidradenoma (also termed clear cell acrospiroma), nodular hidradenoma (also termed nodular acrospiroma, clear cell myoepithelioma, and eccrine sweat gland adenoma of the clear cell type), and solid-cystic hidradenoma variants;{{cite journal | vauthors = Al-Adawi SS, Al-Qasabi B, Al-Bahri M, Aljarrah A, Al-Aghbari S | title = Clear Cell Hidradenoma of the Breast Diagnosed on a Core Needle Biopsy: A case report and review of the literature | journal = Sultan Qaboos University Medical Journal | volume = 20 | issue = 3 | pages = e357–e361 | date = August 2020 | pmid = 33110653 | pmc = 7574794 | doi = 10.18295/squmj.2020.20.03.017 | url = }} 2) the myoepitheliomas; and 3) the poromas, particularly their dermal duct tumor (also termed dermal duct poroma) and hidroacanthoma simplex variants. However, the literature on the acrospiromas is confusing and often terms their variants with different and interchangeable names.{{cite journal | vauthors = Helwig EB | title = Eccrine acrospiroma | journal = Journal of Cutaneous Pathology | volume = 11 | issue = 5 | pages = 415–20 | date = October 1984 | pmid = 6096424 | doi = 10.1111/j.1600-0560.1984.tb00398.x | s2cid = 221605975 | url = }}

Acrospiromas, while by definition benign skin tumors, may recur at the sites of their surgical removal and, uncommonly, progress to malignant tumors such as the malignant hidradenomas, i.e. hidradenocarcinomas, malignant myoepitheliomas,{{cite journal | vauthors = Macagno N, Sohier P, Kervarrec T, Pissaloux D, Jullie ML, Cribier B, Battistella M | title = Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors | journal = Cancers | volume = 14 | issue = 3 | date = January 2022 | page = 476 | pmid = 35158743 | pmc = 8833812 | doi = 10.3390/cancers14030476 | url = | doi-access = free }} and malignant poromas, i.e. porocarcinomas. Further information on the acrospiromas, malignant acrospiromas, and their variants are in the linkages to them in this article.