Activating protein 2

{{Short description|Family of transcription factors}}

{{infobox protein

| Name = transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

| image =

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| caption =

| Symbol = TFAP2A

| AltSymbols = TFAP2, AP2TF

| ATC_prefix=

| ATC_suffix=

| ATC_supplemental=

| CAS_number=

| CAS_supplemental=

| DrugBank=

| EntrezGene = 7020

| HGNCid = 11742

| OMIM = 107580

| PDB =

| RefSeq = NM_003220

| UniProt = P05549

| ECnumber =

| Chromosome = 6

| Arm = p

| Band = 22.3

| LocusSupplementaryData =

}}

{{infobox protein

| Name = transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

| image =

| width =

| caption =

| Symbol = TFAP2B

| AltSymbols = AP2-B

| ATC_prefix=

| ATC_suffix=

| ATC_supplemental=

| CAS_number=

| CAS_supplemental=

| DrugBank=

| EntrezGene = 7021

| HGNCid = 11743

| OMIM = 601601

| PDB =

| RefSeq = NM_003221

| UniProt = Q92481

| ECnumber =

| Chromosome = 6

| Arm = p

| Band = 12

| LocusSupplementaryData =

}}

{{infobox protein

| Name = transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

| image =

| width =

| caption =

| Symbol = TFAP2C

| AltSymbols =

| ATC_prefix=

| ATC_suffix=

| ATC_supplemental=

| CAS_number=

| CAS_supplemental=

| DrugBank=

| EntrezGene = 7022

| HGNCid = 11744

| OMIM = 601602

| PDB =

| RefSeq = NM_003222

| UniProt = Q92754

| ECnumber =

| Chromosome = 20

| Arm = q

| Band = 13.2

| LocusSupplementaryData =

}}

{{infobox protein

| Name = transcription factor AP-2 delta (activating enhancer binding protein 2 delta)

| image =

| width =

| caption =

| Symbol = TFAP2D

| AltSymbols = TFAP2BL1

| ATC_prefix=

| ATC_suffix=

| ATC_supplemental=

| CAS_number=

| CAS_supplemental=

| DrugBank=

| EntrezGene = 83741

| HGNCid = 15581

| OMIM = 610161

| PDB =

| RefSeq = NM_172238

| UniProt = Q7Z6R9

| ECnumber =

| Chromosome = 6

| Arm = p

| Band = 12.3

| LocusSupplementaryData =

}}

{{infobox protein

| Name = transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)

| image =

| width =

| caption =

| Symbol = TFAP2E

| AltSymbols = AP2E

| ATC_prefix=

| ATC_suffix=

| ATC_supplemental=

| CAS_number=

| CAS_supplemental=

| DrugBank=

| EntrezGene = 339488

| HGNCid = 30774

| OMIM =

| PDB =

| RefSeq = NM_178548

| UniProt = Q6VUC0

| ECnumber =

| Chromosome = 1

| Arm = p

| Band = 34.3

| LocusSupplementaryData =

}}

Activating Protein 2 (AP-2) is a family of closely related transcription factors{{cite journal |vauthors =Williams T, Tjian R |title=Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins |journal=Science |volume=251 |issue=4997 |pages=1067–71 |year=1991 |pmid=1998122 |doi= 10.1126/science.1998122|bibcode=1991Sci...251.1067W }}{{cite journal |vauthors =Williams T, Tjian R |title=Analysis of the DNA-binding and activation properties of the human transcription factor AP-2 |journal=Genes Dev. |volume=5 |issue=4 |pages=670–82 |year=1991 |pmid=2010091 |doi= 10.1101/gad.5.4.670|doi-access=free }} which plays a critical role in regulating gene expression during early development.{{cite journal |vauthors =Hilger-Eversheim K, Moser M, Schorle H, Buettner R |title=Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control |journal=Gene |volume=260 |issue=1–2 |pages=1–12 |year=2000 |pmid=11137286 |doi= 10.1016/S0378-1119(00)00454-6}}