Activation syndrome
Activation syndrome is a form of stimulation (sometimes suicidal) or agitation that has been observed in association with some psychoactive drugs.{{Cite web |url=http://www.breggin.com/recentregulatory.pbreggin.2006.pdf |title=Recent regulatory 2006 |access-date=2010-06-14 |archive-date=2011-07-08 |archive-url=https://web.archive.org/web/20110708092908/http://www.breggin.com/recentregulatory.pbreggin.2006.pdf |url-status=dead }} A causative role has not been established.{{cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/018936s102lbl.pdf |title=www.accessdata.fda.gov |format= |access-date=}}
Treatment
Serotonin reuptake inhibitors (SSRI) have been associated with a state of restlessness, lability, agitation, and anxiety termed "activation syndrome". In some people, this state change can increase suicidal tendencies, especially in those under age 25 and during the initial weeks of treatment. SSRI-induced activation syndrome is well-accepted by clinicians.{{cite journal | pmc = 2867356 | pmid=20473344 | doi=10.1007/s10566-010-9095-5 | volume=39 | title=Development and Psychometric Evaluation of the Treatment-Emergent Activation and Suicidality Assessment Profile | year=2010 | journal=Child Youth Care Forum | pages=113–124 |vauthors=Reid JM, Storch EA, Murphy TK, Bodzin D, Mutch PJ, Lehmkuhl H, Aman M, Goodman WK | issue=2 }}
It is unclear whether jitteriness/anxiety syndrome predicts either good or poor prognosis (level D). {{cite journal | doi=10.1192/bjp.bp.107.048371 | volume=194 | title=Antidepressant-inducedjitteriness/anxiety syndrome:systematicreview | journal=The British Journal of Psychiatry | pages=483–490 | author1=Lindsey I. Sinclair | author2=David M. Christmas | author3=Sean D. Hood | author4=John P. Potokar | author5=Andrea Robertson | author6=Andrew Isaac | author7=Shrikant Srivastava | author8=David J. Nutt | author9=Simon J.C. Davies| date=2009 | issue=6 | pmid=19478285 | doi-access=free }}
References
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Category:Syndromes affecting the nervous system
Category:Substance-related disorders
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