Active chromatin sequence
{{Short description|Region of DNA in a eukaryotic chromosome}}
File:Heterochromatin vs. euchromatin.svg
An active chromatin sequence (ACS) is a region of DNA in a eukaryotic chromosome in which histone modifications such as acetylation lead to exposure of the DNA sequence thus allowing binding of transcription factors and transcription to take place. Active chromatin may also be called euchromatin. ACSs may occur in non-expressed gene regions which are assumed to be "poised" for transcription. The sequence once exposed often contains a promoter to begin transcription. At this site acetylation or methylation can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation can cause the gene to be repressed if not being expressed.
See also
References
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- {{cite journal |vauthors =Sabo PJ, Humbert R, Hawrylycz M |title=Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue=13 |pages=4537–42 |date=March 2004 |pmid=15070753 |pmc=384782 |doi=10.1073/pnas.0400678101 |bibcode=2004PNAS..101.4537S |display-authors=etal|doi-access=free }}
- {{cite journal|pmc=551575 | pmid=15706033 | doi=10.1101/gad.1272505 | volume=19 | issue=5 | title=Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping |vauthors=Roh TY, Cuddapah S, Zhao K | journal=Genes Dev | pages=542–52| year=2005 }}
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