Acute basophilic leukemia
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{{Infobox medical condition (new)
| name = Acute basophilic leukemia
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| field = Hematology and oncology
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Acute basophilic leukemia (ABL) is a very rare & clinically aggressive subtype of acute myeloid leukemia (AML) designated by the WHO as a distinct entity within the subcategory of AML, Not Otherwise Specified (NOS),{{cite journal | vauthors = Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JK, Chen W, Chen X, Chng WJ, Choi JK, Colmenero I, Coupland SE, Cross NC, De Jong D, Elghetany MT, Takahashi E, Emile JF, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li XQ, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A | title = The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | journal = Leukemia | volume = 36 | issue = 7 | pages = 1703–1719 | date = July 2022 | pmid = 35732831 | pmc = 9252913 | doi = 10.1038/s41375-022-01613-1 }} which accounts for roughly 4-5% of all "acute non-lymphocytic" cases of leukemia.{{cite journal | vauthors = Zhang Y, Xiao L, LYu L, Zhang L | title = Construction of a predictive model for bone metastasis from first primary lung adenocarcinoma within 3 cm based on machine learning algorithm: a retrospective study | journal = PeerJ | volume = 12 | issue = | pages = e17098 | date = 2024 | pmid = 38495760 | pmc = 10944632 | doi = 10.7717/peerj.17098 | doi-access = free | quote = Figure 1: SEER database patient selection process. }} ABL can be either primary (sporadic) or secondary to an existing bone marrow neoplasm (commonly CML or AML with BCR-ABL1).{{cite journal | vauthors = Valent P, Sotlar K, Blatt K, Hartmann K, Reiter A, Sadovnik I, Sperr WR, Bettelheim P, Akin C, Bauer K, George TI, Hadzijusufovic E, Wolf D, Gotlib J, Mahon FX, Metcalfe DD, Horny HP, Arock M | title = Proposed diagnostic criteria and classification of basophilic leukemias and related disorders | journal = Leukemia | volume = 31 | issue = 4 | pages = 788–797 | date = April 2017 | pmid = 28090091 | pmc = 7115817 | doi = 10.1038/leu.2017.15 }} In either case, the disease is characterized by rapid proliferation of abnormal basophils & immature blasts in the bone marrow and peripheral blood. This process interferes with normal blood cell production, giving rise to classic symptoms of AML & ultimately bone marrow failure.{{cite journal | vauthors = Singh G | title = Acute Basophilic Leukemia: Recent Molecular and Diagnostic Update | journal = Cureus | volume = 14 | issue = 6 | pages = e26054 | date = June 2022 | pmid = 35865433 | doi = 10.7759/cureus.26054 | doi-access = free | pmc = 9289198 }} Given the role of basophils in coordinating histamine release during inflammatory reactions, those with ABL also typically experience symptoms of hyper-histaminemia which can manifest cutaneously & within the gastrointestinal tract.
Signs and symptoms
Common clinical manifestations can include:
- hyper-histaminemia: urticaria, pruritus, edema, hyperpigmentation, lytic bone lesions
- gastrointestinal involvement: ulcers, dyspepsia, nausea, vomiting, diarrhea
- fever
- weight loss
- loss of appetite
- fatigue
- pallor
- easy bruising
- frequent infections
- organomegaly
Genetic risk factors
Similar to other subtypes of AML, sporadic cases of ABL typically arise from genetic mutations disrupting normal hematopoiesis in the bone marrow. However, ABL to this point, lacks a defining genetic abnormality. Thus far, it has been found to be cytogenetically heterogeneous but frequently associated with Philadelphia chromosome in CML & AML with t(9;22) BCR-ABL1.{{cite journal | vauthors = Duchayne E, Demur C, Rubie H, Robert A, Dastugue N | title = Diagnosis of acute basophilic leukemia | journal = Leukemia & Lymphoma | volume = 32 | issue = 3–4 | pages = 269–278 | date = January 1999 | pmid = 10037024 | doi = 10.3109/10428199909167387 }}
Recently, a particular translocation of interest has come into focus due to its recurrence in sporadic cases of ABL observed in male infants. The t(X;6)(p11;q23) translocation results in the formation of MYB-GATA1 fusion gene, which enhances the expression of cellular markers of immaturity, such as CD34 and limit further differentiation. Expression of this fusion gene also directly activates the transcription of two important cell membrane receptors. When active, NTRK1 (neurotrophic receptor tyrosine kinase 1) and IL-1RL1 (ligands of IL-1 receptor-like 1) induce myeloblasts to differentiate into basophils, which likely contributes to the profound basophilia observed in cases of ABL.{{cite journal | vauthors = Ducassou S, Prouzet-Mauléon V, Deau MC, Brunet de la Grange P, Cardinaud B, Soueidan H, Quelen C, Brousset P, Pasquet JM, Moreau-Gaudry F, Arock M, Mahon FX, Lippert E | title = MYB-GATA1 fusion promotes basophilic leukaemia: involvement of interleukin-33 and nerve growth factor receptors | journal = The Journal of Pathology | volume = 242 | issue = 3 | pages = 347–357 | date = July 2017 | pmid = 28418072 | doi = 10.1002/path.4908 }}
Diagnosis
Comprehensive clinical workup for ABL can include any of the following: complete blood count (CBC), serum chemistries, inflammatory markers (ESR/CRP), bone marrow aspiration + biopsy, immunohistochemical stains, electron microscopy, immunophenotyping, peripheral blood smear, chromosomal analysis + FISH panel to rule out MDS/MPD, molecular studies & cytogenic analysis, reverse transcription(RT)-PCR to evaluate for presence of BCR-ABL1, JAK2 & other oncogenic mutations, and CT scan to evaluate for organomegaly/LN involvement.
Consensus diagnostic criteria of ABL, as specified according to the AML subtypes, defined by differentiation markers according to the WHO:
| class="wikitable sortable"
| colspan="1" rowspan="1" |Blasts & immature/mature basophils with metachromasia on toluidine blue staining |
| colspan="1" rowspan="1" |Blasts are negative for cytochemical MPO, SBB, and NSE |
| colspan="1" rowspan="1" |No expression of strong CD117 equivalent (to exclude mast cell leukemia) |
| ≥20% blasts in bone marrow and/or peripheral blood* |
| Criteria for AML types with defined genetic alterations are not met* |
| Criteria for mixed-phenotype acute leukemia are not met (relevant for AML with minimal differentiation)* |
| Not fulfilling diagnostic criteria for myeloid neoplasm post cytotoxic therapy* |
| No prior history of myeloproliferative neoplasm* |
| (*) indicates criteria shared by all groups within this subclass |
Another proposed diagnostic criteria of basophilic leukemia that subcategorizes the disease as either acute (ABL) vs chronic (CBL), based on the percentage of blasts (myeloblasts and metachromatic blasts) in the BM & PB.
Acute Basophilic Leukemia:
| class="wikitable"
| colspan="1" rowspan="1" |hyperbasophilia (persistent peripheral basophil count ⩾ 1000 per μl of blood) |
| colspan="1" rowspan="1" |percentage of basophils ≥ 40% of total leukocytes in bone marrow or peripheral blood |
| colspan="1" rowspan="1" |myeloblasts + metachromatic blasts ≥ 20% of total leukocytes in bone marrow or peripheral blood |
Chronic Basophilic Leukemia:
| class="wikitable"
| colspan="1" rowspan="1" |hyperbasophilia (persistent peripheral basophil count ⩾ 1000 per μl of blood) |
| colspan="1" rowspan="1" |percentage of basophils ≥ 40% of total leukocytes in bone marrow or peripheral blood |
| colspan="1" rowspan="1" |myeloblasts + metachromatic blasts < 20% of total leukocytes in bone marrow or peripheral blood |
Treatment
Given the aggressive nature of ABL, patients will likely need stem cell transplant. Those patients who are not candidates for transplant require chemotherapy or targeted immunotherapy in combination with prophylactic antihistamines agents for symptomatic support.
Prognosis
References
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External links
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| DiseasesDB =
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| ICDO = 9870/3
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| MeshID = D015471
| SNOMED CT = 69077002
| Orphanet = 86849
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{{Myeloid malignancy}}
Category:Acute myeloid leukemia
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