Adenosylcobinamide-phosphate synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Adenosylcobinamide-phosphate synthase

| EC_number = 6.3.1.10

| CAS_number = 905988-16-1

| GO_code =

| image =

| width =

| caption =

}}

Adenosylcobinamide-phosphate synthase ({{EnzExplorer|6.3.1.10}}, CbiB) is an enzyme with systematic name adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming).{{cite journal | vauthors = Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I | title = Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica | journal = Biochemistry | volume = 41 | issue = 15 | pages = 4798–808 | date = April 2002 | pmid = 11939774 | doi = 10.1021/bi012111w | citeseerx = 10.1.1.564.9386 }}{{cite journal | vauthors = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Natural Product Reports | volume = 19 | issue = 4 | pages = 390–412 | date = August 2002 | pmid = 12195810 | doi = 10.1039/b108967f }} This enzyme catalyses the following chemical reaction

: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate $\backslash rightleftharpoons$ ADP + phosphate + adenosylcobinamide phosphate

: (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol $\backslash rightleftharpoons$ ADP + phosphate + adenosylcobinamide

One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD ({{EC number|4.1.1.81}}). This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.