Adenovirus vaccine

{{About|vaccination against adenoviruses|adenoviruses as vaccine vectors|Viral vector vaccine#Adenovirus}}

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| type = vaccine

| image = TEVA adenovirus.jpg

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| caption = Bottles of the vaccine

| target = Adenovirus

| vaccine_type = Live virus

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| Drugs.com = {{drugs.com|monograph|adenovirus-vaccine}}

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| DailyMedID = Adenovirus type

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| routes_of_administration = Oral administration

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| legal_US = Rx-only

| legal_US_comment = {{cite web | title=Adenovirus Type 4 and Type 7 Vaccine, Live kit | website=DailyMed | date=26 July 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7d0b43c-7250-4809-8a05-fcde5862f076 | access-date=8 September 2023}}{{cite web | title=Adenovirus Type 4 and Type 7 Vaccine, Live, Oral | website=U.S. Food and Drug Administration (FDA) | date=15 October 2019 | url=https://www.fda.gov/vaccines-blood-biologics/vaccines/adenovirus-type-4-and-type-7-vaccine-live-oral | access-date=8 September 2023 | id=STN: BL 125296 }}

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| DrugBank = DB14409

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| UNII = FKD3DUK39I

| UNII2 = TM54L796SN

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An adenovirus vaccine is a vaccine against adenovirus infection.{{cite journal |vauthors =Tucker SN, Tingley DW, Scallan CD |title=Oral adenoviral-based vaccines: historical perspective and future opportunity |journal=Expert Rev Vaccines |volume=7 |issue=1 |pages=25–31 |date=February 2008|pmid=18251691 |doi=10.1586/14760584.7.1.25 |s2cid=7058518 }} According to the American CDC, "There is currently no adenovirus vaccine available to the general public.{{Cite web |date=2023-04-27 |title=Adenovirus Vaccine Information Statement {{!}} CDC |url=https://www.cdc.gov/vaccines/hcp/vis/vis-statements/adenovirus.html |access-date=2023-10-30 |website=www.cdc.gov |language=en-us}}

It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.{{cite journal |display-authors=etal |vauthors=Croyle MA, Patel A, Tran KN |year=2008 |editor1-last=Doolan |editor1-first=Denise L. |title=Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice |journal=PLOS ONE |volume=3 |issue=10 |pages=e3548 |bibcode=2008PLoSO...3.3548C |doi=10.1371/journal.pone.0003548 |pmc=2569416 |pmid=18958172 |doi-access=free}}{{cite journal |vauthors=Hartman ZC, Appledorn DM, Amalfitano A |date=March 2008 |title=Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications |journal=Virus Res. |volume=132 |issue=1–2 |pages=1–14 |doi=10.1016/j.virusres.2007.10.005 |pmc=4039020 |pmid=18036698}}{{cite journal |vauthors=Tatsis N, Ertl HC |date=October 2004 |title=Adenoviruses as vaccine vectors |journal=Mol. Ther. |volume=10 |issue=4 |pages=616–29 |doi=10.1016/j.ymthe.2004.07.013 |pmc=7106330 |pmid=15451446 |doi-access=free}}

US military

It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production.{{cite journal |vauthors =Russell KL, Hawksworth AW, Ryan MA |title=Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004 |journal=Vaccine |volume=24 |issue=15 |pages=2835–42 |date=April 2006|pmid=16480793 |pmc=1955759 |doi=10.1016/j.vaccine.2005.12.062 |display-authors=etal}}{{cite web |url=http://www.navy.mil/search/display.asp?story_id=26369 |title=Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits |access-date=15 January 2009| archive-url= https://web.archive.org/web/20090212011026/http://www.navy.mil/search/display.asp?story_id=26369| archive-date= 12 February 2009 | url-status= dead}} This vaccine elicited immunity to adenovirus serotypes 4 and 7,{{cite journal |title=Two fatal cases of adenovirus-related illness in previously healthy young adults--Illinois, 2000 |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=50 |issue=26 |pages=553–5 |date=July 2001|pmid=11456329 |author1= Centers for Disease Control and Prevention (CDC)}} the serotypes most often associated with acute respiratory disease. On 16 March 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army.Malarkey MA, Baylor NW. FDA approval letter dated 16 March 2011. This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.{{cite journal|vauthors=Choudhry A, Mathena J, Albano JD, Yacovone M, Collins L |title=Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits|journal=Vaccine|volume=34|issue=38|pages=4558–4564|date=31 August 2016|doi=10.1016/j.vaccine.2016.07.033|pmid=27475474|doi-access=free}}

The vaccine is orally administered and consists of live (not attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.[https://www.fda.gov/media/80211/download Package insert for Adenovirus Type 4 and Type 7 Vaccine, Live, Oral], fda.gov, accessed 9 July 2020

References

External links

{{cite web | title=Adenovirus Vaccine Information Statement | publisher=U.S. Centers for Disease Control and Prevention (CDC) | date=January 2020 | url=https://www.cdc.gov/vaccines/hcp/vis/vis-statements/adenovirus.html }}
{{MeshName|Adenovirus Vaccines}}

Category:Adenoviridae

Category:Vaccines