Adrenal ferredoxin

Adrenodoxin is a small iron-sulfur protein that can accept and carry a single electron. Adrenodoxin functions as an electron transfer protein in the mitochondrial cytochrome P450 systems.{{cite journal | vauthors = Hanukoglu I, Jefcoate CR | title = Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin | journal = The Journal of Biological Chemistry | volume = 255 | issue = 7 | pages = 3057–61 | date = Apr 1980 | doi = 10.1016/S0021-9258(19)85851-9 | pmid = 6766943 | url = http://www.jbc.org/content/255/7/3057.full.pdf | doi-access = free }} The first enzyme in this system is adrenodoxin reductase that carries an FAD. FAD can be reduced by two electrons donated from coenzyme NADPH.{{cite journal | vauthors = Hanukoglu I | title = Conservation of the Enzyme-Coenzyme Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme | journal = Journal of Molecular Evolution | volume = 85 | issue= 5 | pages= 205–218 | year= 2017 | pmid= 29177972 | doi= 10.1007/s00239-017-9821-9 | bibcode = 2017JMolE..85..205H | s2cid = 7120148 }} These two electrons are transferred one a time to adrenodoxin. Adrenodoxin in return reduces mitochondrial cytochrome P450. This particular oxidation/reduction system is involved in the synthesis of steroid hormones in steroidogenic tissues. In addition, similar systems also function in vitamin D and bile acid synthesis in the kidney and liver respectively. Adrenodoxin has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific.

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• {{UCSC gene info|FDX1}}

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