Adrenodoxin-NADP+ reductase

{{Infobox enzyme

| Name = Adrenodoxin-NADP⁺ reductase

| EC_number = 1.18.1.6

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

Adrenodoxin-NADP⁺ reductase ({{EC number|1.18.1.6}}, adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP⁺ oxidoreductase.{{cite journal | title = Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase | vauthors = Omura T, Sanders E, Estabrook RW, Cooper DY, Rosenthal O |journal = Arch. Biochem. Biophys. |year = 1966 |volume = 117 | issue = 3 |pages = 660–673 |doi=10.1016/0003-9861(66)90108-1}}{{cite journal | vauthors = Chu JW, Kimura T | title = Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein) | journal = The Journal of Biological Chemistry | volume = 248 | issue = 6 | pages = 2089–94 | date = March 1973 | pmid = 4144106 }}{{cite journal | vauthors = Sugiyama T, Yamano T | title = Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria | journal = FEBS Letters | volume = 52 | issue = 1 | pages = 145–8 | date = March 1975 | pmid = 235468 | doi = 10.1016/0014-5793(75)80658-2 | doi-access = }}{{cite journal | vauthors = Hanukoglu I, Jefcoate CR | title = Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin | journal = The Journal of Biological Chemistry | volume = 255 | issue = 7 | pages = 3057–61 | date = April 1980 | pmid = 6766943 }}{{cite journal | vauthors = Hanukoglu I, Hanukoglu Z | title = Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation | journal = European Journal of Biochemistry | volume = 157 | issue = 1 | pages = 27–31 | date = May 1986 | pmid = 3011431 | doi = 10.1111/j.1432-1033.1986.tb09633.x | url = https://zenodo.org/record/890737 | doi-access = free }}{{cite journal | vauthors = Hanukoglu I, Gutfinger T | title = cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases | journal = European Journal of Biochemistry | volume = 180 | issue = 2 | pages = 479–84 | date = March 1989 | pmid = 2924777 | doi = 10.1111/j.1432-1033.1989.tb14671.x | url = https://zenodo.org/record/890733 | doi-access = free }}{{cite journal | vauthors = Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE | title = The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis | journal = Journal of Molecular Biology | volume = 289 | issue = 4 | pages = 981–90 | date = June 1999 | pmid = 10369776 | doi = 10.1006/jmbi.1999.2807 }} This enzyme catalyses the following chemical reaction

: 2 reduced adrenodoxin + NADP⁺ $\backslash rightleftharpoons$ 2 oxidized adrenodoxin + NADPH + H⁺

Adrenodoxin-NADP+ reductase is a flavoprotein (FAD).