Alacrima

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| name = Alacrima

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| field = ophthalmology

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| differential = Triple-A syndrome

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Alacrima refers to an abnormality in tear production that could mean reduced tear production or absent tear production. Because a lack of tears presents in only in a few rare disorders, it aids in diagnosis of these disorders, including Triple-A syndrome and NGLY1 deficiency.{{cite web|url=http://www.ngly1.org/|website=NGLY1 deficiency|title=NGLY1 Foundation|access-date=2015-01-26|archive-date=2015-06-15|archive-url=https://web.archive.org/web/20150615130523/http://www.ngly1.org/|url-status=dead}}{{cite journal |vauthors=Need AC, Shashi V, Hitomi Y, Schoch K, Shianna KV, McDonald MT, Meisler MH, Goldstein DB | title = Clinical application of exome sequencing in undiagnosed genetic conditions | journal = J Med Genet | volume = 49| issue = 6| pages = 353–61|date=May 2012 | pmid = 22581936 | doi = 10.1136/jmedgenet-2012-100819 | pmc=3375064}}{{cite journal |vauthors=Enns GM, Shashi V, Bainbridge M, et al. |title=Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway |journal=Genet. Med. |volume= 16|issue= 10|pages= 751–8|date=March 2014 |pmid=24651605 |doi=10.1038/gim.2014.22 |pmc=4243708}}

Alacrima can be formally diagnosed through a Schirmer's test.