Aldehyde dehydrogenase (NADP+)

{{infobox enzyme

| Name = Aldehyde dehydrogenase (NADP+)

| EC_number = 1.2.1.4

| CAS_number = 9028-87-9

| GO_code =

| image =

| width =

| caption =

}}

In enzymology, an aldehyde dehydrogenase (NADP+) ({{EC number|1.2.1.4}}) is an enzyme that catalyzes the chemical reaction

:an aldehyde + NADP⁺ + H₂O $\rightleftharpoons$ an acid + NADPH + H⁺

The 3 substrates of this enzyme are aldehyde, NADP⁺, and H₂O, whereas its 3 products are acid, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NADP+ oxidoreductase. Other names in common use include NADP+-acetaldehyde dehydrogenase, NADP+-dependent aldehyde dehydrogenase, and aldehyde dehydrogenase (NADP+). This enzyme participates in caprolactam degradation.

References

{{cite journal | vauthors = Adachi O, Matsushita K, Shinagawa E, Ameyama M | date = 1980 | title = Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus | journal = Agric. Biol. Chem. | volume = 44 | pages = 155–164 | doi=10.1271/bbb1961.44.155| doi-access = free }}
Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
{{cite journal | author = Nakayama T | location = Tokyo | title = Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase | journal = J. | volume = Biochem. | pages = 812–830 }}
{{cite journal | author = SEEGMILLER JE | date = 1953 | title = Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast | journal = J. Biol. Chem. | volume = 201 | pages = 629–37 | pmid = 13061400 | issue = 2 }}

Category:EC 1.2.1

Category:NADPH-dependent enzymes

Category:Enzymes of unknown structure